Effect of 3 Day Pre-operative Immunonutrition Regimen on Clinical Outcome in Well-nourished Patients With Gastrointestinal Cancer Undergoing Surgery , a Randomised Double-blind Controlled Trial
Inclusion Criteria:
- Patients with GI cancer (stomach, pancreas, small and large bowel and rectum)
histologically proven
- Well nourished patients as defined by a total score of <3 on the nutritional
screening tool NRS-2002 (46) (Appendix III)
- Patients who are >= 18 years of age;
- Patients who have signed a written Informed Consent (Appendix I) prior to admission
to the study;
- Patients who have an ECOG performance status of 0, 1 or 2 (Appendix II).
- Patients able to orally consume 750 mL or more of liquid a day prior to surgery
Exclusion Criteria:
- Patients who have co-morbid conditions, uncontrolled metabolic conditions or
psychiatric conditions that might make tolerance or evaluation of the feeding formula
difficult;
- Patients who are pregnant;
- Patients with cardiac failure as defined by the Goldman classification class>3
- Patients with respiratory failure (FEV<0.8l/sec)
- Patients with renal failure (Cr >= 3mg/dl or dialysis patients)
- Patients with hepatic dysfunction (Child >A)
- Patients suffering from an intestinal obstruction or ileum
- Patients with an Hb level of <=8 g/dL experiencing gastrointestinal hemorrhaging
- Patients with HIV, HCV, HBV
- Patients requiring immunosuppression treatments
- Patients undergoing emergency surgery
- Other patients determined by a study investigator to be inappropriate for enrolment
in this study