Inclusion Criteria:

- 19 Years and older

- Histologically or cytologically confirmed locally advanced or metastatic NSCLC(Stage
IIIB or IV)

- ≥ one measureable or evaluable lesion, <25% of the bone marrow had been irradiated

- prior platinum based chemotherapy

- ECOG PS ≤ 2

- Life expectancy > 3 months

- Adequate organ function:

- hematology: ANC ≥ 1.5×109/L, Platelet ≥ 100×109/L, hemoglobin ≥ 9.0g/dL

- hepatic: total bilirubin ≤ 1.5×ULN, AST/ALT ≤ 2.0×ULN, ALP ≤2.0×ULN

- renal: serum creatinine ≤ 1.5×ULN

- Signed a written informed consent

Exclusion Criteria:

- Active infection

- Symptomatic brain lesion

- Any other type of cancer during the previous 5 years except appropriately treated
basal cell carcinoma of the skin or in situ carcinoma of the cervix

- Severe concurrent diseases

- Prior anticancer therapy within 4 weeks before enroll

- Active pregnancy test