Preoperative Accelerated Partial Breast Irradiation (APBI) for Women With Stage I and Select IIA Breast Cancer
This study will evaluate the feasibility, cosmetic results, complication rates, and local
control rate of 3D-CRT confined to the region of the lumpectomy cavity for patients with
Stage I and IIa (less than or equal to 3 cm) carcinoma of the breast (non-lobular histology)
treated with APBI using 3D-CRT before lumpectomy. For selected patients with Stage I and II
breast carcinoma, 3D-CRT delivered to the primary tumor preoperatively is technically
reproducible with acceptable complication rates. Cosmetic results after partial breast
irradiation before lumpectomy will be comparable to that obtained after whole breast
external beam radiation therapy. The local tumor control rate in the breast after partial
breast irradiation therapy followed by lumpectomy will be comparable to that of conventional
external beam radiation therapy, with less inconvenience and potentially less cost to the
patient, given the selection criteria which minimize the risk of clinically significant
multicentric or extensive residual carcinoma following lumpectomy.
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
The primary endpoint of this study is determination of the reproducibility of delivering preoperative APBI in Stage I and Stage IIA breast cancers.
This will be done by using 3D-CRT by evaluating the prescription isodose curves, dose inhomogeneity, and coverage of the volume as defined by CT treatment planning to delineate the target volume.
Steven Feigenberg, MD
UMMC MSGCC Department of Radiation Oncology
United States: Institutional Review Board
|Central Maryland Oncology Center||Columbia, Maryland 21044|
|Ummc Msgcc||Baltimore, Maryland 21201|
|Baltimore Washington Medical Center||Glen Burnie, Maryland 21061|