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A Phase I Trial of Escalating Doses of the Anti-IGF-1R Monoclonal Antibody IMC-A12 and Standard Dose Sorafenib for Treatment of Advanced Hepatocellular Carcinoma

Phase 1
19 Years
Open (Enrolling)
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer

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Trial Information

A Phase I Trial of Escalating Doses of the Anti-IGF-1R Monoclonal Antibody IMC-A12 and Standard Dose Sorafenib for Treatment of Advanced Hepatocellular Carcinoma


I. To establish the maximum tolerated dose (MTD) of IMC-A12 given in conjunction with
standard doses of sorafenib to patients with advanced hepatocellular carcinoma (HCC).

II. To describe the toxicity and tolerance of IMC-A12 at each dose studied in combination
with standard-dose sorafenib in patients with advanced HCC.

III. To evaluate the impact of IMC-A12 on biomarkers related to the IGF-1R/IGF pathway which
is thought relevant to HCC progression and drug resistance.

IV. To obtain preliminary assessments of efficacy through description of progression-free
survival (PFS) and objective response rate (RR).

OUTLINE: This is a multicenter, dose-escalation study of cixutumumab followed by an extended
accrual phase in which patients are treated at the maximum-tolerated dose.

Patients receive cixutumumab IV over 1 hour on days 1, 8, 15, and 22 and oral sorafenib
tosylate twice daily on days 1-28. Courses repeat every 28 days in the absence of disease
progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically.

Inclusion Criteria:

- Unresectable or metastatic HCC for which standard curative measures do not exist; the
diagnosis of hepatocellular carcinoma should be based on at least one of the

- The presence of one or more liver lesions, measuring ≥ 2 cm, with characteristic
arterial enhancement and venous washout in the setting of liver cirrhosis and/or
hepatitis B or C infection

- The presence of liver lesion(s) with AFP >= 400

- Tissue confirmation in the absence of a and/or b

- Tissue availability is desired and will be sought, but tissue availability is
not mandated for accrual to the study

- No prior systemic therapy for HCC; patients may have had prior embolization,
chemoembolization, intra-arterial chemotherapy infusion, ethanol injection,
radiofrequency ablation or cryosurgery

- ECOG 0 or 1

- Life expectancy of greater than 3 months

- Absolute neutrophil count > 1,000/mm^3

- Platelets > 65,000/mm^3

- Total bilirubin =< 2 x the institutional upper normal limit

- AST and ALT =< 5 x the institutional upper normal limit

- Renal function =< 1.5 mg/dl or calculated creatinine clearance > 50 mL/min
(Cockcroft-Gault formula)

- PT < 4 seconds of prolongation above the upper normal limit

- No evidence of encephalopathy in the last 6 months

- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry and
for the duration of study participation; should a woman become pregnant or suspect
she is pregnant while participating in this study, she should inform her treating
physician immediately

- Ability to understand and willing to sign a written informed consent document

Exclusion Criteria:

- Local therapy for HCC within 4 weeks prior to treatment on this study or those who
have not recovered from adverse events related to therapy administered more than 4
weeks earlier

- Receiving other investigational agents

- Brain metastases, because of their poor prognosis, proclivity for progressive
neurologic dysfunction that would confound the evaluation of neurologic adverse
events, and the potential for increased risk for CNS adverse events

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant women are excluded from this study; breastfeeding should be discontinued if
the mother is treated on this clinical trial

- HIV-positive patients are ineligible

- Fasting blood glucose > 160 mg/dL

- Esophageal or gastric variceal bleeding within the last 6

- Clinically evident ascites (minimal, medically controlled ascites detectable on
imaging studies only is allowed)

- Child-Pugh C cirrhosis or Child-Pugh B cirrhosis with more than 7 points

- Patients unable to swallow the sorafenib tablets whole are ineligible; (the tablets
cannot be crushed or broken)

- Cardiac: symptomatic congestive heart failure, unstable angina, clinically
significant and uncontrolled cardiac dysrhythmia, uncontrolled hypertension (systolic
BP > 150 or diastolic BP > 100 on two occasions within two weeks of beginning therapy
on this protocol, myocardial infarction within 6 months, NYHA class > II, LVEF <
normal as assessed on MUGA

- Fibrolamellar carcinoma or any mixed variants of HCC with fibrolamellar histology

- Hypersensitivity to human IgG unless the patient has subsequently tolerated IgG

- Patients with active hepatitis B infection should be on adequate antiviral therapy

Type of Study:


Study Design:

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

MTD defined as the highest IMC-A12 dose tested in which none or only one patient had a dose-limiting toxicity (DLT) attributed to IMC-A12 as assessed by NCI CTCAE version 4.0

Outcome Description:

The toxicities observed at each dose level will be summarized in terms of type (organ affected or laboratory determination such as absolute neutrophil count), severity (by CTCAE and nadir or maximum values for the laboratory measures), time of onset (i.e. course number), duration, and reversibility or outcome. Tables will be created to summarize these toxicities and side effects by dose and by course.

Outcome Time Frame:

First 1 month of therapy

Safety Issue:


Principal Investigator

Robert O'Donnell

Investigator Role:

Principal Investigator

Investigator Affiliation:

UC Davis Comprehensive Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

August 2009

Completion Date:

Related Keywords:

  • Adult Primary Hepatocellular Carcinoma
  • Advanced Adult Primary Liver Cancer
  • Localized Unresectable Adult Primary Liver Cancer
  • Recurrent Adult Primary Liver Cancer
  • Carcinoma
  • Liver Neoplasms
  • Carcinoma, Hepatocellular



UC Davis Comprehensive Cancer CenterSacramento, California  95817