Outcomes of Oncology Therapy in the Elderly: Trajectory of Functional Decline and Correlates of Change
The study looks at functional change of elderly cancer patients. Approximately 52 cancer
patients age 65 or older will be asked to participate. Cancer patients asked to participate
will be receiving cancer therapy with the intention of providing a cure. Functional change
will be assessed from the time of diagnosis, through therapy to the early post therapy time
frame. A comprehensive model explaining reasons for function change is used as the
framework for choosing variables to measure. Components of function that will be measured
include a 6 minute walk test, lower extremity muscle strength, a Short Physical Performance
Battery assessing function of legs and a test that simulates typical household activities.
Surveys will be used to subjects own assessment of their activity and function. The four
most common cancer-related side effects will be measured and include fatigue, sleep
impairment, shortness of breath and pain. Some markers in the blood may be abnormal and be
related to declines in function. They will also be measured. Differences in function over
time will be determined and relationships between function, cancer-related side effects and
quality of life will be assessed.
Observational Model: Cohort, Time Perspective: Prospective
Determine change from baseline of physical function in elderly cancer patients after oncologic therapy.
Baseline, post therapy, 3 months post therapy
Dittus Kim, MD
University of Vermont
United States: Institutional Review Board
Oncology therapy in elderly
|University of Vermont/Fletcher Allen Health Care||Burlington, Vermont 05405|