Genetic Polymorphisms in ALL Samples Submitted to Gene Array Analysis
OBJECTIVES:
- Collect DNA samples from patients with cytogenetically, well characterized, and
uniformly treated acute lymphoblastic leukemia or acute myeloid leukemia for use in
analysis of a wide range of host factors influencing etiology and outcome of the
disease.
- Identify host factors that can be determined at onset of treatment to predict outcome
of chemotherapy, and thus modify the therapy administered.
OUTLINE: Previously collected DNA samples are analyzed for polymorphisms at a variety of
loci. Gene expression and expression profiles are correlated with genotype and therapy
outcomes.
Observational
N/A
Collection of DNA samples for use in analysis of a wide range of host factors influencing etiology and outcome of disease
No
Stella M. Davies, MBBS, PhD
Study Chair
Children's Hospital Medical Center, Cincinnati
United States: Federal Government
CDR0000271322
NCT01005277
April 2002
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