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Genetic Polymorphisms in ALL Samples Submitted to Gene Array Analysis


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Open (Enrolling)
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Leukemia

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Trial Information

Genetic Polymorphisms in ALL Samples Submitted to Gene Array Analysis


OBJECTIVES:

- Collect DNA samples from patients with cytogenetically, well characterized, and
uniformly treated acute lymphoblastic leukemia or acute myeloid leukemia for use in
analysis of a wide range of host factors influencing etiology and outcome of the
disease.

- Identify host factors that can be determined at onset of treatment to predict outcome
of chemotherapy, and thus modify the therapy administered.

OUTLINE: Previously collected DNA samples are analyzed for polymorphisms at a variety of
loci. Gene expression and expression profiles are correlated with genotype and therapy
outcomes.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- DNA samples available from patients meeting the following criteria:

- Infants with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML)

- Patients with pre-B ALL, including responders vs non-responders in selected
genotypes [hyperdiploid, hypodiploid, t(12;21), t(9;22), t(1;19), and t(4;11)]
and responders and non-responders regardless of genotype

- Pediatric patients with AML registered on POG-9421

- Adult patients with ALL, including t(8.21), inv(16), t(15;17), complex
cytogenetics, and secondary AML

- Pediatric patients with relapsed ALL enrolled on COG-AALL01P2

- Pediatric patients enrolled on COG-9900 and other CCG or POG trials

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Collection of DNA samples for use in analysis of a wide range of host factors influencing etiology and outcome of disease

Safety Issue:

No

Principal Investigator

Stella M. Davies, MBBS, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Children's Hospital Medical Center, Cincinnati

Authority:

United States: Federal Government

Study ID:

CDR0000271322

NCT ID:

NCT01005277

Start Date:

April 2002

Completion Date:

Related Keywords:

  • Leukemia
  • childhood acute lymphoblastic leukemia in remission
  • recurrent childhood acute lymphoblastic leukemia
  • childhood acute myeloid leukemia in remission
  • childhood acute myeloid leukemia/other myeloid malignancies
  • recurrent childhood acute myeloid leukemia
  • secondary acute myeloid leukemia
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with t(15;17)(q22;q12)
  • adult acute myeloid leukemia with t(8;21)(q22;q22)
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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