Trial Information

Does Short-term Structured Exercise Training Program Plus Diet Intervention Improve Ovarian Sensitivity to Clomiphene Citrate in Polycystic Ovary Syndrome Patients (PCOS)? A Prospective Randomized Controlled Study

Ninety-six PCOS patients considered CC-resistant because not responsive to 150 mg daily of
CC were randomized in three arms (group A, B, and C). Group A underwent SET program plus
hypocaloric diet for two months, group B had one month of observation followed by one-cycle
of CC therapy, and group C underwent SET program plus hypocaloric diet for two months and
received one-cycle of CC for one cycle. CC was always given at the maximal dose previously
used. Clinical, hormonal and metabolic data were assessed at baseline and after
intervention. Ovulation was monitored by ultrasound and confirmed by plasma progesterone
assay.