Inclusion Criteria:

- have advanced or metastatic pancreatic adenocarcinoma who have not previously
received any chemotherapy or biotherapy. Patients who have received radiotherapy
with or without radiotherapy enhancers (such as low dose 5-FU) will be eligible.

- have evidence of measurable disease. However, lesions in a previous radiation field
are considered non-evaluable for response. Therefore, patients must have a
measurable lesion that is not in a previously irradiated field to be eligible.

- have NO continuing acute toxic effects (except alopecia) of any prior radiotherapy or
surgical procedures, i.e., all such effects must have resolved to Common Terminology
Criteria for Adverse Events (CTCAE, Version 3.0) Grade ≤1. Surgery (except biopsies)
must have occurred at least 28 days prior to study enrolment.

- have received NO radiotherapy within 28 days prior to receiving study drug.

- have an ECOG Performance Score ≤ 2.

- have a life expectancy of at least 3 months.

- absolute neutrophil count (ANC) ≥ 1.5 x 10^9 [SI units 10^9/L]; Platelets ≥ 100 x10^9
[SI units 10^9/L] (without platelet transfusion); Serum creatinine ≤ 1.5 x ULN;
Bilirubin ≤ 1.5 x ULN; AST/ALT ≤ 2.5 x ULN (≤ 5 x ULN if patients have liver
metastasis).

- negative pregnancy test for females of childbearing potential.

Exclusion Criteria:

- no concurrent therapy with any other investigational anticancer agent while on study.

- have a history of or current evidence of brain metastasis(es).

- be on immunosuppressive therapy; have known HIV infection or active hepatitis B or C.

- be a pregnant or breast-feeding woman.

- have clinically significant cardiac disease.

- have dementia or altered mental status that would prohibit informed consent.

- have any other severe, acute, or chronic medical or psychiatric condition or
laboratory abnormality that may increase the risk associated with study participation
or study drug administration or may interfere with the interpretation of study
results and, in the judgment of the Principal Investigator, would make the patient
inappropriate for this study.