Prospective Analysis Group

Inclusion Criteria:

- Patients about to receive intravenous cisplatin for the first time as part of cancer
chemotherapy.

- Aged 18 years and older.

- Ability to understand and willingness to sign a written consent document.

- Patients may be receiving cisplatin in combination with other chemotherapeutic
agents.

- Patients may be receiving cisplatin in the context of another clinical trial.

Exclusion Criteria:

- Prior receipt of cisplatin.

- Patients on dialysis or other renal replacement therapy prior to starting cisplatin.

- Uncontrolled hypo- or hyperthyroidism (patients on chronic stable doses of thyroid
replacement medication are eligible).

Retrospective Analysis Group

Inclusion Criteria:

- Patients that have previously received intravenous cisplatin as part of cancer
chemotherapy.

- Aged 18 years and older.

- Ability to understand and willingness to sign a written consent document.

- Patients that received cisplatin in combination with other chemotherapeutic agents
are eligible.

- Patients that received cisplatin in the context of a clinical trial are eligible.

Exclusion Criteria:

- Unable or unwilling to submit to a one-time blood draw.