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Colorectal Cancer Screening in Cancer Survivors Treated With Radiation Therapy


N/A
35 Years
49 Years
Open (Enrolling)
Both
Colorectal Cancer

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Trial Information

Colorectal Cancer Screening in Cancer Survivors Treated With Radiation Therapy


Cancer survivors meeting the COG criteria for CRC screening will undergo colonoscopy and
removal of colorectal polyps. Documentation of polyp number, location and pathologic
characteristics will be made. Clinical data information will also be collected at the time
of patient enrollment.


Inclusion Criteria:



1. Asymptomatic survivors treated with ≥ 25Gy to the abdomen, pelvis or spine, or ≥ 12Gy
total body radiation therapy, or ≥ 12Gy whole abdominal RT.

2. Patients who have passed ≥10 years following RT

3. Patients whose current age is 35-49.

Exclusion Criteria:

1. Patients with signs/symptoms suggestive of CRC or other high-risk features such as:

- Persistent constipation for >2 weeks in the last month

- One or more unexplained episodes of red blood in the stool in the last month

- One or more unexplained episodes of black stool in the last month

- Unexplained pelvic pain in the last month

2. Patients with a history of Crohn's disease or ulcerative colitis

3. Patients already taking part in a colorectal screening program defined as any
colorectal screening (colonoscopy, sigmoidoscopy, fecal occult blood test) within
last 5 years.

4. Patients with self-reported history of colorectal polyps.

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Outcome Measure:

The proportion of screened patients with any polyp or any high risk polyp will be calculated.

Outcome Time Frame:

3 years

Safety Issue:

No

Principal Investigator

David Hodgson, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Health Network, Princess Margaret Hospital

Authority:

Canada: Ethics Review Committee

Study ID:

UHN REB 07-0708-CE

NCT ID:

NCT00982059

Start Date:

May 2008

Completion Date:

March 2014

Related Keywords:

  • Colorectal Cancer
  • Colorectal cancer screening
  • Cancer survivor
  • Radiation therapy
  • Cancer Survivor
  • Colorectal Neoplasms

Name

Location

Dana-Farber Cancer InstituteBoston, Massachusetts  02115