Inclusion Criteria:

- Pathologically proven non-resectable adenocarcinoma of stomach

- Measurable disease based on Response Criteria in Solid Tumors (RECIST)

- Prior chemotherapy with taxane, fluoropyrimidine, and cisplatinum in combination
or sequentially, there is no time limit for the last chemotherapy

- Age 18 to 70 years old

- Estimated life expectancy of more than 3 months

- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or lower

- Adequate bone marrow function (white blood cell counts >4,000/µL, absolute neutrophil
count [ANC]>1,500/µL, hemoglobin >9.0 g/dL, and platelets>100,000/µL),

- Adequate kidney function (creatinine<1.5 mg/dL)

- Adequate liver function (bilirubin<1.5 mg/dL , transaminases levels<3 times the upper
normal limit [5 times for patients with liver metastasis], and serum albumin of >2.5
mg/dL)

Exclusion Criteria:

- Other tumor type than adenocarcinoma

- Presence or history of central nervous system metastasis

- Obvious or impending bowel obstruction (including obvious peritoneal carcinomatosis)

- Evidence of active gastrointestinal bleeding

- Other serious illness or medical conditions