Combined Metformin and Clomiphene Citrate Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-resistant Women With Polycystic Ovary Syndrome
All patients in the combined metformin-CC group received metformin HCl (Cidophage®;Chemical
Industries Development,Cairo, Egypt), 500 mg thrice daily for 6-8 weeks. Then after the end
of this period, they received 100 mg CC (Clomid®; Global Napi Pharmaceuticals,Cairo, Egypt)
for 5 days starting from day 3 of menstruation (increased by 50 mg in the next cycle in case
of anovulation ). Patients continued treatment for up to six cycles. Metformin was stopped
only when pregnancy was documented. All patients in the control group underwent laparoscopic
ovarian diathermy, then followed up for 6 months.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
occurrence of ovulation and midcycle endometrial thickness (mm).
Hatem Abu Hashim, MD. MRCOG
Mansoura University Hospitals
Egypt: Institutional Review Board