Inclusion Criteria:

- Ability to give written informed consent and be able to adhere to dose and visit
schedules.

- Diagnosis of an advanced colorectal, breast, gastric/esophageal or pancreatic cancer
with liver metastases that are amenable to biopsy.

- Histological or cytological evidence of malignancy.

- Advanced metastatic colorectal, breast, gastric/esophageal or pancreatic cancer that
has recurred or progressed following standard therapy or failed standard therapy; or
for which no standard therapy currently exists, or for which subject is not a
candidate for, or is unwilling to undergo standard therapy.

Note: Additional tumor histologies may be eligible based on available HGF/c-Met pathway
data and approval by the Sponsor.

- Disease that is currently not amenable to curative surgical intervention.

- Male or female and ≥ 18 years of age.

- ECOG performance status of 0-1.

- Measurable p-Met by immunohistochemistry in archived or otherwise available tumor
sample.

- Female subjects of childbearing potential must have negative pregnancy test within 5
days prior to first dose of study drug.

- Female subjects of childbearing potential and male subjects whose sexual partners are
of childbearing potential must agree to abstain from sexual intercourse or to use an
effective method of contraception during the study and for 60 days after the last
dose of AV-299 (formerly SCH 900105). Examples of effective methods of contraception
include oral contraceptives or double barrier methods such as condom plus spermicide
or condom plus diaphragm.

- Adequate hematologic function as evidenced by Hg ≥ 9g/dL, WBC ≥ 3000 per mm3, ANC ≥
1500 per mm3 and platelet count ≥ 100,000 per mm3.

- Adequate hepatic function as evidenced by a serum bilirubin level ≤ 1.5 × ULN (except
with known Gilbert's Syndrome) and with serum AST/ALT levels ≤ 5 × ULN.

- Adequate renal function as evidenced by a serum creatinine level ≤ 1.5 × ULN or a
calculated creatinine clearance > 60 mL/min.

- Adequate coagulation function as evidenced by PTT ≤ 1.5 × ULN and INR ≤ 1.5 × ULN.

- Recovery from the effects of any prior surgery, radiotherapy, or systemic
antineoplastic therapy.

- Subjects with abnormal liver function tests (LFTs) who have not been screened for
Hepatitis B or C within the past 6 months prior to study enrollment, will need to be
screened for Hepatitis B and C and can only be enrolled if the screening is negative.

Exclusion Criteria:

- Women who are breast-feeding, pregnant, or intend to become pregnant.

- Hematologic malignancies.

- Any of the following within 6 months prior to administration of study drug:

- Myocardial infarction (MI), severe/unstable angina pectoris, coronary/peripheral
artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident,
transient ischemic attack or seizure disorder.

- Serious/symptomatic active infection, or infection requiring antibiotics, within 14
days prior to first dose of study drug.

- Persistent, unresolved CTCAE v3.0 Grade 2 or higher drug-related toxicity (except
alopecia, erectile dysfunction, hot flashes, decreased libido, and Grade 2 sensory
peripheral neuropathy) associated with previous treatment.

- Inadequate recovery from any prior surgical procedure or major surgical procedure
performed within 4 weeks prior to administration of first dose of study drug.

- Any other medical or psychiatric condition that, in the opinion of the investigator,
might interfere with the subject's participation in the trial or interfere with the
interpretation of trial results.

- Known Human Immunodeficiency Virus (HIV) infection or a known HIV-related malignancy.

- Known active hepatitis B or C.

- Known hypersensitivity to any of the components of SCH 900105.

- Known bleeding diathesis.

- Radiotherapy within 3 weeks prior to first study drug administration.

- Inability to comply with the protocol requirements, including inability to undergo
liver biopsies.

- Participation in any other clinical trials involving therapeutic agents.

- Any medications prohibited in the study.

- Active alcohol or illicit drug abuse.

- Stem cell/bone marrow transplant within 6 months of first dose of study drug.