Propranolol vs Prednisolone for Infant Hemangiomas-A Clinical and Molecular Study
Infants with symptomatic hemangiomas will be enrolled. Magnetic resonance imaging will be
completed before starting medication if the extent of the hemangioma is not evident on
clinical examination alone. Infants will be randomized to receive either propranolol or
steroids for 4-6 months. Hemangioma response will be measured and compared monthly as will
tolerability of the medications. Additionally, urine specimens will be collected at each
visit to determine if markers are present that can predict response to therapy.
Additionally, any hemangiomas that are excised will be examined for genetic markers to aid
in predicting response to therapy.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
reduction in size of hemangioma
Nancy M Bauman, MD
Children's Research Institute, Children's National Medical Center
United States: Institutional Review Board
|Children's National Medical Center||Washington, District of Columbia 20010-2970|