Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.
The aim of the present study is to investigated the genetic alterations in tumor samples of
a series of all WHO-defined subtypes of thymoma patients using high resolution microarray-
comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the
data to identify specific patterns of genetic aberrations and genes associated with each
subtype. Moreover, tumor samples will be also investigated for some specific potential
therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ
hybridization (FISH) analysis. All these biological data will be correlated with clinical
patients characteristics and survival data.
Observational Model: Cohort, Time Perspective: Retrospective
Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.
Armando Santoro, MD
Istituto Clinico Humanitas
Italy: Ministry of Health