Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.
18 Years
N/A
Both
Thymoma
Trial Information
Biological Analysis of a Series of Thymoma and Thymic Carcinoma: Genetic Aberrations and Potential Therapy Targets.
The aim of the present study is to investigated the genetic alterations in tumor samples of
a series of all WHO-defined subtypes of thymoma patients using high resolution microarray-
comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the
data to identify specific patterns of genetic aberrations and genes associated with each
subtype. Moreover, tumor samples will be also investigated for some specific potential
therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ
hybridization (FISH) analysis. All these biological data will be correlated with clinical
patients characteristics and survival data.
Inclusion Criteria:
- Availability of tumor tissue and patients with thymoma and thymic carcinoma
Exclusion Criteria:
- NON Availability of tumor tissue and patients with thymoma and thymic carcinoma
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Retrospective
Outcome Measure:
Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets.
Outcome Time Frame:
one year
Safety Issue:
No
Principal Investigator
Armando Santoro, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Istituto Clinico Humanitas
Authority:
Italy: Ministry of Health
Study ID:
ONC/OSS-01/2008
NCT ID:
NCT00965627
Start Date:
June 2008
Completion Date:
August 2009
Related Keywords:
- Thymoma
- Thymoma
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