Retrospective Study of Genetic Risk Factors for Osteosarcoma
N/A
N/A
Both
Sarcoma
Trial Information
Retrospective Study of Genetic Risk Factors for Osteosarcoma
OBJECTIVES:
Primary
- Conduct a large-scale candidate gene-association study in patients with osteosarcoma
using cases from clinical trials COG-P9851 and COG-AOST06B1.
Secondary
- Conduct a genome-wide association study of osteosarcoma.
- Fine-map genomic regions associated with osteosarcoma to identify putative functional
loci.
- Investigate the functional implications of promising genetic variants associated with
osteosarcoma.
OUTLINE: This is a multicenter study.
Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and
haplotypes to examine genetic variation, gene-gene interactions, and the population
structure.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Blood samples collected from clinical trials COG-P9851 and COG-AOST06B1
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Gene associations
Safety Issue:
No
Principal Investigator
Sharon A. Savage, MD
Investigator Role:
Study Chair
Investigator Affiliation:
National Cancer Institute - EPN
Authority:
United States: Federal Government
Study ID:
CDR0000633101
NCT ID:
NCT00954473
Start Date:
January 2009
Completion Date:
Related Keywords:
- Sarcoma
- localized osteosarcoma
- metastatic osteosarcoma
- recurrent osteosarcoma
- Osteosarcoma
- Sarcoma
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