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Protocol to Obtain Bone Marrow for Research


N/A
17 Years
N/A
Open (Enrolling)
Both
Bone Marrow Biopsy

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Trial Information

Protocol to Obtain Bone Marrow for Research


The purpose of this study is to determine the mechanisms that regulate human globin gene
expression by analyzing the function of cell signaling pathways and the expression of other
related genes and their protein products in the bone marrow cells of people without blood
diseases. This includes the effects of drugs and other in vitro manipulations of the cells
once they are removed from donors. These assays will include, but are not limited to,
determinations of DNA methylation status, histone acetylation profiles, DNAse sensitivity,
transcription factor binding to DNA, levels of various proteins, messenger RNAs and miRNAs
in the cells of the marrow samples. By understanding how this process occurs in people
without blood diseases, we hope to to design future treatments for people with diseases such
as sickle cell disease and B-thalassemia.


Inclusion Criteria:



- Patients undergoing diagnostic bone marrow biopsies at the Norris Cotton Cancer
Center of DHMC.

- Patients undergoing bone marrow harvesting for autologous bone marrow
transplantation.

- Normal donors undergoing bone marrow harvesting for autologous bone marrow
transplantation.

- Normal persons over the age of 17 who volunteer to undergo bone marrow aspiration.

Exclusion Criteria:

- Normal volunteers with known allergies to lidocaine (or similar analgesics)or
betadine.

Type of Study:

Observational

Study Design:

Observational Model: Cohort

Principal Investigator

Christopher H Lowrey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center

Authority:

United States: Institutional Review Board

Study ID:

D0529

NCT ID:

NCT00951925

Start Date:

June 2005

Completion Date:

Related Keywords:

  • Bone Marrow Biopsy
  • Any patient undergoing diagnostic bone marrow biopsies
  • Any patient undergoing bone marrow harvesting for autologous bone marrow transplantation.

Name

Location

Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire  03756