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A Phase III Clinical Trial of Bevacizumab With IV Versus IP Chemotherapy in Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma NCI-Supplied Agent(s): Bevacizumab (NSC #704865, IND #7921)

Phase 3
18 Years
Open (Enrolling)
Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma, Ovarian Mucinous Cystadenocarcinoma, Ovarian Serous Cystadenocarcinoma, Ovarian Undifferentiated Adenocarcinoma, Stage IIA Fallopian Tube Cancer, Stage IIA Ovarian Epithelial Cancer, Stage IIA Primary Peritoneal Cavity Cancer, Stage IIB Fallopian Tube Cancer, Stage IIB Ovarian Epithelial Cancer, Stage IIB Primary Peritoneal Cavity Cancer, Stage IIC Fallopian Tube Cancer, Stage IIC Ovarian Epithelial Cancer, Stage IIC Primary Peritoneal Cavity Cancer, Stage IIIA Fallopian Tube Cancer, Stage IIIA Ovarian Epithelial Cancer, Stage IIIA Primary Peritoneal Cavity Cancer, Stage IIIB Fallopian Tube Cancer, Stage IIIB Ovarian Epithelial Cancer, Stage IIIB Primary Peritoneal Cavity Cancer, Stage IIIC Fallopian Tube Cancer, Stage IIIC Ovarian Epithelial Cancer, Stage IIIC Primary Peritoneal Cavity Cancer, Stage IV Fallopian Tube Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Primary Peritoneal Cavity Cancer

Thank you

Trial Information

A Phase III Clinical Trial of Bevacizumab With IV Versus IP Chemotherapy in Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma NCI-Supplied Agent(s): Bevacizumab (NSC #704865, IND #7921)


I. To determine if one or both of the proposed intraperitoneal chemotherapy regimens
improves the progression-free survival (PFS) event rate compared to standard intravenous
chemotherapy for first-line treatment of patients diagnosed with advanced stage ovarian,
peritoneal or fallopian tube cancer.

II. If both IP regimens significantly improve the PFS event rate compared to the standard
regimen, then a second study objective is to determine whether IP cisplatin and IV
paclitaxel on day one plus IP paclitaxel on day eight improves the PFS event rate when
compared to the IP carboplatin and IV paclitaxel.


I. To determine if intraperitoneal chemotherapy reduces the overall death rate compared to
standard intravenous chemotherapy.

II. To assess the frequency and severity of adverse events as defined by CTCAE version 3.0.

III. To compare the patient-reported outcomes on: Quality of Life (FACT-O-TOI), Neuropathy
(FACT-GOG/NTX4 scale), Abdominal discomfort (FACT-GOG/AD scale), Fatigue (FACIT-Fatigue
scale), and Nausea (item from FACT-O-TOI).

IV. To assess the frequency and the reasons for early discontinuation of the study


I. To bank DNA from whole blood for research and examine the association between single
nucleotide polymorphisms (SNPs) and measures of clinical outcome including overall survival,
progression-free survival and adverse events.

II. To bank archival tumor for research and examine the association between tumor markers
and measures of clinical outcome including overall survival, progression-free survival and
adverse events.

III. Patients will be encouraged to enroll on the companion translational research protocol
(CEM0703 under development).

OUTLINE: This is a multicenter study. Patients are stratified according to disease stage
(FIGO stage II vs stage III vs stage IV) and size of residual disease after initial
staging/debulking surgery (no gross residual disease vs gross residual disease with lesion ≤
1 cm vs any gross residual disease with lesion > 1 cm). Patients are randomized to 1 of 3
treatment arms.

ARM I: Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and carboplatin IV
over 30 minutes on day 1. Patients also receive bevacizumab IV over 30-90 minutes on day 1
in courses 2-6. Treatment repeats every 21 days for 6 courses in the absence of disease
progression or unacceptable toxicity. Patients then receive bevacizumab alone in courses
7-22 in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive paclitaxel as in arm I and carboplatin intraperitoneally (IP) on
day 1. Patients also receive bevacizumab as in arm I. Treatment repeats every 21 days for 6
courses in the absence of disease progression or unacceptable toxicity. Patients then
receive bevacizumab alone as in arm I.

ARM III: Patients receive paclitaxel IV over 3 hours on day 1, cisplatin IP on day 2, and
paclitaxel IP on day 8. Patients also receive bevacizumab as in arm I. Treatment repeats
every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Patients then receive bevacizumab alone as in arm I.

Patients complete quality-of-life questionnaires at baseline and at weeks 9, 18, 36, 60, and
84. Blood and tissue samples may be collected for further laboratory analysis.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then annually for 5 years.

Inclusion Criteria:

- Histologically confirmed ovarian epithelial, fallopian tube, or primary peritoneal
carcinoma, including any of the following epithelial cell types*:

- Serous adenocarcinoma

- Endometrioid adenocarcinoma

- Mucinous**adenocarcinoma

- Undifferentiated carcinoma

- Clear** cell adenocarcinoma

- Mixed epithelial carcinoma

- Transitional cell carcinoma

- Malignant Brenner tumor

- Adenocarcinoma not otherwise specified

- Stage II, III, or IV disease with either optimal (≤ 1 cm residual disease) or
suboptimal residual disease

- Must have undergone surgery for diagnosis, staging, and/or cytoreduction within the
past 12 weeks

- Prior or concurrent primary endometrial cancer allowed provided the primary origin of
the invasive tumor is ovarian or peritoneal and all of the following criteria are

- Stage of endometrial cancer is ≤ IB

- No more than superficial myometrial invasion, without vascular or lymphatic

- No poorly differentiated subtypes, including papillary serous, clear cell, or
other FIGO grade 3 lesions

- No borderline ovarian epithelial tumor ("tumors of low malignant potential") (e.g.,
stage IA or IB disease with low-grade lesions)

- Patients with a prior diagnosis of a borderline tumor that was surgically
resected and who subsequently develop an unrelated, new invasive ovarian
epithelial or primary peritoneal cancer are eligible provided they have not
received prior chemotherapy for any ovarian tumor

- No recurrent invasive ovarian epithelial cancer treated with surgery only

- No history or evidence of major CNS disease by physical examination (e.g., primary
brain tumor, metastatic cancer in the brain, seizures not controlled with standard
medical therapy, or any brain metastases within the past 6 months

- No metastatic tumor in the parenchyma of the liver or lungs with proximity to large

- GOG performance status 0-2

- ANC ≥ 1,500/mm³ (without granulocyte colony-stimulating factor support)

- Platelet count ≥ 100,000/mm³

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST and ALT ≤ 2.5 times ULN

- Alkaline phosphatase ≤ 2.5 times ULN

- Creatinine normal

- Urine protein:creatinine ratio < 1.0

- PTT <1.5 times ULN

- Concurrent heparin, lovenox or alternative anticoagulants allowed

- PT/INR ≤ 1.5 times ULN (or an in-range INR, usually between 2 and 3, if patient is on
a stable dose of therapeutic warfarin)

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for ≥ 6 months after
completion of study treatment

- No sensory or motor neuropathy > CTCAE grade 1

- No seizures not controlled with standard medical therapy

- No other invasive malignancies within the past 5 years, except nonmelanoma skin

- No acute hepatitis or active infection requiring parenteral antibiotics

- No serious non-healing wound, ulcer, or bone fracture

- Granulating incisions healing by secondary intention allowed provided there is
no evidence of fascial dehiscence or infection AND the wound is examined weekly
during study

- No clinical symptoms or signs of gastrointestinal obstruction and/or those who
require parenteral hydration and/or nutrition

- Patients with a history or current diagnosis of inflammatory bowel disease are
not eligible

- No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within
the past 28 days

- No active bleeding or pathologic condition that carries a high risk of bleeding
(e.g., known bleeding disorder, coagulopathy, or tumor involving major vessels)

- No cerebrovascular accident (stroke), transient ischemic attack, or subarachnoid
hemorrhage within the past 6 months

- No clinically significant cardiovascular disease, including any of the following:

- Uncontrolled hypertension, defined as systolic BP > 150 mmHg or diastolic BP >
90 mmHg

- Myocardial infarction or unstable angina within the past 6 months

- NYHA class II-IV congestive heart failure

- Serious cardiac arrhythmia requiring medication

- Asymptomatic atrial fibrillation with controlled ventricular rate or
history of supraventricular tachycardia controlled with medications and
asymptomatic allowed

- Peripheral vascular disease ≥ CTCAE grade 2 (at least brief [< 24 hrs] episodes
of ischemia managed non-surgically and without permanent deficit)

- No history or evidence of cerebrovascular accident (CVA, stroke), transient ischemic
attack, or subarachnoid hemorrhage within the past 6 months

- No known hypersensitivity to Chinese hamster ovary cell products or other recombinant
human or humanized antibodies

- No known allergy to Cremophor or polysorbate 80

- No significant traumatic injury within the past 28 days

- No other medical history or condition (e.g., persistent gastrointestinal symptoms
resulting from clostridia difficile enterocolitis or bowl surgery; or hearing loss or
neuropathy) that, in the opinion of the investigator, would preclude study

- Concurrent ovarian estrogen (with or without progestin) replacement therapy for
control of menopausal symptoms allowed provided the lowest effective dose(s) is (are)

- No concurrent high-dose of progestins as an appetite stimulant

- No prior radiotherapy to any portion of the abdominal cavity or pelvis

- Prior radiotherapy for localized cancer of the breast, head and neck, or skin
allowed provided it was completed > 3 years ago AND patient remains free of
recurrent or metastatic disease

- No prior chemotherapy for any abdominal or pelvic tumor, including neoadjuvant
chemotherapy for ovarian or primary peritoneal cancer

- Prior adjuvant chemotherapy for localized breast cancer allowed provided it was
completed > 3 years ago AND patient remains free of recurrent or metastatic

- No prior targeted therapy (including vaccines, antibodies, or tyrosine kinase
inhibitors) or hormonal therapy for management of ovarian epithelial or primary
peritoneal cancer

- No prior anti-VEGF therapy, including bevacizumab

- No prior cancer treatment that would contraindicate study treatment

- More than 7 days since prior core biopsy

- More than 28 days since prior major surgical procedure or open biopsy

- No concurrent major surgical procedure, including, but not limited to, abdominal
surgery (laparotomy or laparoscopy) before disease progression (e.g., colostomy or
enterostomy reversal, secondary cytoreductive surgery, or second-look surgery)

- No other concurrent anti-neoplastic therapy, including cytotoxic therapy, biologic
therapy, hormonal therapy, or radiotherapy

- No concurrent amifostine or other protective reagents

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Progression-free survival

Outcome Time Frame:

From date that each patient is enrolled onto the study to the date of the patient's first failure event, assessed up to 10 years

Safety Issue:


Principal Investigator

Joan Walker

Investigator Role:

Principal Investigator

Investigator Affiliation:

Gynecologic Oncology Group


United States: Food and Drug Administration

Study ID:




Start Date:

July 2009

Completion Date:

Related Keywords:

  • Brenner Tumor
  • Ovarian Clear Cell Cystadenocarcinoma
  • Ovarian Endometrioid Adenocarcinoma
  • Ovarian Mixed Epithelial Carcinoma
  • Ovarian Mucinous Cystadenocarcinoma
  • Ovarian Serous Cystadenocarcinoma
  • Ovarian Undifferentiated Adenocarcinoma
  • Stage IIA Fallopian Tube Cancer
  • Stage IIA Ovarian Epithelial Cancer
  • Stage IIA Primary Peritoneal Cavity Cancer
  • Stage IIB Fallopian Tube Cancer
  • Stage IIB Ovarian Epithelial Cancer
  • Stage IIB Primary Peritoneal Cavity Cancer
  • Stage IIC Fallopian Tube Cancer
  • Stage IIC Ovarian Epithelial Cancer
  • Stage IIC Primary Peritoneal Cavity Cancer
  • Stage IIIA Fallopian Tube Cancer
  • Stage IIIA Ovarian Epithelial Cancer
  • Stage IIIA Primary Peritoneal Cavity Cancer
  • Stage IIIB Fallopian Tube Cancer
  • Stage IIIB Ovarian Epithelial Cancer
  • Stage IIIB Primary Peritoneal Cavity Cancer
  • Stage IIIC Fallopian Tube Cancer
  • Stage IIIC Ovarian Epithelial Cancer
  • Stage IIIC Primary Peritoneal Cavity Cancer
  • Stage IV Fallopian Tube Cancer
  • Stage IV Ovarian Epithelial Cancer
  • Stage IV Primary Peritoneal Cavity Cancer
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Brenner Tumor
  • Carcinoma
  • Cystadenocarcinoma
  • Peritoneal Neoplasms
  • Fallopian Tube Neoplasms
  • Carcinoma, Endometrioid
  • Cystadenocarcinoma, Mucinous
  • Cystadenocarcinoma, Serous
  • Neoplasms, Glandular and Epithelial
  • Ovarian Neoplasms



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Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Medini, Eitan MD (UIA Investigator)Alexandria, Minnesota  56308
Miller-Dwan HospitalDuluth, Minnesota  55805
Unity HospitalFridley, Minnesota  55432
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator)Great Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Community Medical HospitalMissoula, Montana  59801
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Hunterdon Medical CenterFlemington, New Jersey  08822
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington CountyMount Holly, New Jersey  08060
Virtua West Jersey Hospital VoorheesVoorhees, New Jersey  08043
New York University Langone Medical CenterNew York, New York  10016
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Alamance Regional Medical CenterBurlington, North Carolina  27216
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Marietta Memorial HospitalMarietta, Ohio  45750
University of ToledoToledo, Ohio  43614
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Wright-Patterson Medical CenterWright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare SystemZanesville, Ohio  43701
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Northwest Cancer Specialists-Rose Quarter Cancer CenterPortland, Oregon  97227
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Geisinger Wyoming ValleyWilkes-Barre, Pennsylvania  18711
Greenville CCOPGreenville, South Carolina  29615
Greenville Memorial HospitalGreenville, South Carolina  29605
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Peninsula Cancer Institute-Newport NewsNewport News, Virginia  23601
Harrison Bremerton Hematology and OncologyBremerton, Washington  98310
Swedish Medical Center-First HillSeattle, Washington  98122-4307
Saint Joseph Medical CenterTacoma, Washington  98405
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Saint Michael's HospitalStevens Point, Wisconsin  54481
University of California Medical Center At Irvine-Orange CampusOrange, California  92868
Cancer Care Associates-YaleTulsa, Oklahoma  74136-1929
Women and Infants HospitalProvidence, Rhode Island  02905
Colorado Gynecologic Oncology GroupAurora, Colorado  80010
Lake University Ireland Cancer CenterMentor, Ohio  44060
Lyndon Baines Johnson General HospitalHouston, Texas  77030
Women's Cancer AssociatesSaint Petersburg, Florida  33701
Stony Brook University Medical CenterStony Brook, New York  11794
Lahey Clinic Medical CenterBurlington, Massachusetts  01805
Elkhart ClinicElkhart, Indiana  46515
John Muir Medical Center-Concord CampusConcord, California  94520
Marin General HospitalGreenbrae, California  94904
University of Colorado Cancer Center - Anschutz Cancer PavilionAurora, Colorado  80045
Kootenai Cancer CenterPost Falls, Idaho  83854
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-CottageGalesburg, Illinois  61401
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Cancer Center of Kansas-LiberalLiberal, Kansas  67901
Commonwealth Hematology Oncology PC-WorcesterWorcester, Massachusetts  01605
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
University of Missouri - Ellis FischelColumbia, Missouri  65203
Hackensack University Medical CCOPHackensack, New Jersey  07601
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
Duke Raleigh HospitalRaleigh, North Carolina  27609
Annie Penn Memorial HospitalReidsville, North Carolina  27320
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation OncologyGreer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical OncologyGreer, South Carolina  29650
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
Saint Paul HospitalDallas, Texas  75235
Utah Valley Regional Medical CenterProvo, Utah  84603
Dixie Medical Center Regional Cancer CenterSaint George, Utah  84770
Intermountain Health CareSalt Lake City, Utah  84103
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Hawaii Minority Based CCOPHonolulu, Hawaii  96813
Advocate Lutheran General HospitalPark Ridge, Illinois  60068
Saint Elizabeth Medical Center SouthEdgewood, Kentucky  41017
Maine Medical Center-Bramhall CampusPortland, Maine  04102
Gynecologic Oncology of West Michigan PLLCGrand Rapids, Michigan  49546
Center of Hope at Renown Medical CenterReno, Nevada  89502
Montefiore Medical Center-Weiler DivisionBronx, New York  10461
Monter Cancer CenterLake Success, New York  11042
Hope, A Women's Cancer CenterAsheville, North Carolina  28816
Magee-Womens Hospital - University of Pittsburgh Medical CenterPittsburgh, Pennsylvania  15213
Black Hills Obstetrics and GynecologyRapid City, South Dakota  57701
Carilion Clinic Gynecological OncologyRoanoke, Virginia  24016
Aurora Women's Pavilion of Aurora West Allis Medical CenterWest Allis, Wisconsin  53227
Long Beach Memorial Medical Center-Todd Cancer InstituteLong Beach, California  90806
Kaiser Permanente Medical Care Program - Los Angeles Medical Center & Sunset HospitalLos Angeles, California  90027
Rocky Mountain Gynecologic Oncology PCEnglewood, Colorado  80110
Saint Vincent's Medical CenterJacksonville, Florida  32204
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida  33136
Bayfront Outpatient Health ClinicSaint Petersburg, Florida  33701
Norton Health Care Pavilion - DowntownLouisville, Kentucky  40202
University of Minnesota Medical Center-FairviewMinneapolis, Minnesota  55455
Southwest Gynecologic Oncology Associates IncAlbuquerque, New Mexico  87106
Women's Cancer Center of NevadaLas Vegas, Nevada  89109
Arizona Cancer Center at University Medical Center NorthTucson, Arizona  85719
Palchak David MDPismo Beach, California  93449
Wilcox Memorial Hospital and Kauai Medical ClinicLihue, Hawaii  96766-1099
Central DuPage Hospital Cancer CenterWarrenville, Illinois  60555
Hematology and Oncology ClinicBaton Rouge, Louisiana  70809
Southern Ohio Medical CenterPortsmouth, Ohio  45662
Providence Regional Cancer PartnershipEverett, Washington  98201
Gundersen LutheranLa Crosse, Wisconsin  54601
Columbia Saint Mary's Water Tower Medical CommonsMilwaukee, Wisconsin  53211
Stanford University Hospitals and ClinicsStanford, California  94305
Walter Reed National Military Medical CenterBethesda, Maryland  20889
Palo Alto Medical Foundation-Gynecologic OncologyMountain View, California  94040
Sudarshan K Sharma MD Limted-Gynecologic OncologyHinsdale, Illinois  60521
Saint Vincent Oncology CenterIndianapolis, Indiana  46260
University of Massachusetts Memorial Health CareWorcester, Massachusetts  01605
PeaceHealth Medical Group PCBellingham, Washington  98226
Skagit Valley Hospital Regional Cancer Care CenterMount Vernon, Washington  98274
Olympic Medical Cancer Care CenterSequim, Washington  98384
Rockwood Cancer Treatment CenterSpokane, Washington  99204
Providence Saint Mary Regional Cancer CenterWalla Walla, Washington  99362
Cancer Institutes of Washington PLLCYakima, Washington  98902
Aurora Saint Luke's Medical CenterMilwaukee, Wisconsin  53215
Norris Cotton Cancer Center-ManchesterManchester, New Hampshire  03104
Jonsson Comprehensive Cancer CenterLos Angeles, California  90095
Alta Bates Summit Medical Center-Herrick CampusBerkeley, California  94704
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Summa Akron City HospitalAkron, Ohio  44304
Park Nicollet Frauenshuh Cancer CenterMinneapolis, Minnesota  55416
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
North Shore-LIJ Health System CCOPManhasset, New York  11030
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Essentia Health Saint Joseph's Medical CenterBrainerd, Minnesota  56401
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Geisinger Medical Center-Cancer Center HazeltonHazleton, Pennsylvania  18201
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Bronson Battle CreekBattle Creek, Michigan  49017
Springfield Regional Medical CenterSpringfield, Ohio  45505
Cleveland Clinic Cancer Center/Fairview HospitalCleveland, Ohio  44111
Saint Joseph's Hospital and Medical CenterPhoenix, Arizona  85013
Southeast Gynecologic Oncology AssociatesJacksonville, Florida  32204
Women's Cancer Care Associates LLCAlbany, New York  12208
Island Gynecologic OncologyBrightwaters, New York  11718
Fletcher Allen Health Care-Medical CenterBurlington, Vermont  05401
Self Regional HealthcareGreenwood, South Carolina  29646
Harrison Poulsbo Hematology and OncologyPoulsbo, Washington  98370
Baylor All Saints Medical Center at Fort WorthFort Worth, Texas  76104
The Women's Oncology CenterSaint Louis, Missouri  63141