Inclusion Criteria:

- Relapsed or refractory acute myelogenous or lymphoid leukemia

- Chronic myelogenous leukemia in accelerated phase or blast-crisis

- Chronic myelogenous leukemia in second or subsequent chronic phase

- Recurrent or refractory malignant lymphoma or Hodgkin's disease

- Multiple myeloma at high risk for disease recurrence

- Chronic lymphocytic leukemia, relapsed or with poor prognostic features

- Other Myeloproliferative disorder (polycythemia vera, essential
thrombocythemia, myelofibrosis) with poor prognostic features

- Myelodysplastic syndromes (including PNH) with > 5% blasts

- Zubroid performance status < 2 (See Appendix B)

- Life expectancy is not severely limited by concomitant illness

- Adequate cardiac and pulmonary function. Patients with decreased LVEF or PFTS will be
evaluated by cardiology or pulmonary prior to enrollment on this protocol

- Calculated Creatinine Clearance > 50 ml/min

- Serum bilirubin 2.0 mg/dl, SGPT < 3x upper limit of normal

- No evidence of chronic active hepatitis or cirrhosis

- HIV-negative

- Patient is not pregnant

- Patient or guardian able to sign informed consent

Exclusion Criteria:

- Clinical progression