Inclusion Criteria:

- Histologically documented breast cancer (either primary or metastatic site) that is
ER-negative, PR-negative, and HER2 non-overexpressing by immunohistochemistry (0, 1) or
fluorescence in situ hybridization (FISH).

Triple-negative tumors were defined by the following criteria:

- HER2-non-overexpressing: FISH-negative (defined by ratio <2.2) or,
immunohistochemical (IHC) 0, IHC 1+ or, IHC 2+ or IHC 3+ and FISH-negative.

- ER- and PR-negative: <10% tumor staining by immunohistochemistry (IHC).

- Never having received chemotherapy for metastatic disease or, having received 1
or 2 prior chemotherapy regimens in the metastatic setting (Prior
adjuvant/neoadjuvant therapy was allowed);

- Metastatic breast cancer (Stage IV) with measurable disease by RECIST 1.1
criteria;

- Female, ≥18 years of age;

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1;

- Organ and marrow function as follows: absolute neutrophil count (ANC) ≥1500/mm3,
platelets ≥100,000/dL, hemoglobin ≥9 g/dL, bilirubin ≤1.5 mg/dL, serum
creatinine ≤1.5 mg/dL or creatinine clearance ≥60 mL/min, alanine
aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 times the upper
limit of normal if no liver involvement or ≤5 times the upper limit of normal
with liver involvement;

- Radiation therapy completed at least 14 days before study dosing on day 1;
radiated lesions may not have served as measurable disease;

- Central nervous system metastases allowed if subject did not require steroids,
whole brain radiation therapy (XRT), gamma/cyber knife, and brain metastases
were clinically stable without symptomatic progression;

- For women of child bearing potential, documented negative pregnancy test within
two weeks of study entry and agreement to acceptable birth control during the
duration of the study therapy;

- Tissue block (primary or metastatic) or readily available fresh frozen tumor
tissue for PARP expression and other pharmacogenomic studies recommended
(although its absence will not exclude subjects from participating);

- No other diagnosis of malignancy (with exception of non melanoma skin cancer or
a malignancy diagnosed ≥5 years ago);

- Obtained informed consent;

- Capability to understand and comply with the protocol and signed informed
consent document.

Exclusion Criteria:

- Systemic anticancer therapy within 14 days of the first dose of study drug;

- Prior treatment with gemcitabine, carboplatin, cisplatin or iniparib

- Had not recovered to grade ≤1 from adverse events (AEs) per National Cancer Institute
Common Terminology Criteria for Adverse Events (NCI-CTCAE) v3.0 or to within 10% of
baseline values due to investigational drugs or other medications administered more
than 30 days prior to study enrollment;

- Major medical conditions that might have affected study participation (e.g.
uncontrolled pulmonary, renal, or hepatic dysfunction, uncontrolled infection,
cardiac disease);

- Concurrent radiation therapy intended to treat primary tumor not permitted throughout
the course of the study; palliative radiation was acceptable;

- Leptomeningeal disease or brain metastases requiring steroids or other therapeutic
intervention;

- Pregnancy or breastfeeding;

- Inability or unwillingness to abide by the study protocol or cooperate fully with the
investigator or designee.