Effect of the Cysteine-rich Whey Protein Isolate (Immunocal®) in Combination With Physical Exercise on Muscle Function, Body Composition and Inflammatory Cytokine Levels in Elderly Persons: A Randomized, Double-blind Study
- Age 65 or older
- Estimated GFR above 45ml/min
- Total bilirubin in the normal range (0.2 to 1.2 mg/dl) AST (10-35 U/L for women and
10-50 U/L for men). ALT equal to or less than 2.5 times the upper limit of normal
- BMI between 18.5-29.9 (kg)/m2
- Sedentary (< 2 hours of structured exercise)in the last 2 or 3 months
- Based on investigator judgment according to current Canadian guidelines, medical
conditions such as hypertension, diabetes and hyperlipidemia have to be stable and
optimally controlled before the subject starts the study.
- History of angioedema or allergic reactions to any compound used in this study.
- Milk protein intolerance
- Subjects currently using N-acetylcysteine, alpha-lipoic acid supplements, or dry whey
- Major surgery in the year prior to testing
- Acute coronary or vascular event within the last year or progressive angina
- Stroke within the past 2 years
- Neurologist and/or orthopedic limitations
- Uncontrolled thyroid or pituitary disease
- Medication which has a major affect on cognitive function
- Signs of early dementia as assessed by Mini-Mental State Examination
- Weight loss of more than 4kg(or more than 5% body weight) over last 6 months
- Alcohol abuse
- Medication which interferes with muscle mass i.e. (corticosteroids)
- Any life threatening conditions based on Investigator judgment.
- Subjects with allergies/intolerance to soya.
- Subjects currently undergoing immunosuppressive therapy.