Trial Information

Breathing Adapted Radiotherapy for Mediastinal Lymphoma

Radiotherapy using a breathing adapted therapy scan is a routine technique in breast cancer.
Breathing adapted radiotherapy may also reduce radiation dose to organs at risk, e.g. heart
and lung, in patients with mediastinal Hodgkin lymphoma and aggressive non-Hodgkin
lymphomas.

Optimal radiation therapy of these lymphoma patients includes radiotherapy planning using
pre-chemotherapy PET-scanning, fused with a post-chemo planning CT-scan. This makes accurate
treatment of pre-chemo involved volume possible and also accurate radiation of the
post-chemo involved volume possible. Thus, the optimal breathing adapted radiation requires
planning using a breathing adapted pre-chemo PET-CT scan fused with a breathing adapted
post-chemo planning CT scan. In this study, 20 consecutive patients with mediastinal Hodgkin
lymphoma and aggressive non-Hodgkin lymphomas will have combination therapy with
chemotherapy and radiation therapy to involved nodes. Two radiation therapy plans will be
made for each patient: one using a breathing adapted pre-chemo PET-CT scan fused with a
post-chemo planning CT scan, and one using the standard procedure of a pre-chemo PET-CT scan
fused with post-chemo planning CT scan. Dose levels to the lymphoma and to the organs of
risk will be compared in each patient. The best radiation therapy plan will be used to treat
the patient.