Trial Information

Familial Colorectal Cancer In Puerto Rico: A Feasibility Study

Data obtained from this two-year pilot study will serve as the foundation for our large,
island-wide, population-based, genetic-epidemiologic study of familial colorectal cancer in
Puerto Rico. Through this feasibility study, we will assess the feasibility: (1) of
recruiting colorectal cancer patients using the PR Central Cancer Registry, (2) of
evaluating family pedigrees and recruiting the relatives of probands (3) obtaining tumor,
blood, medical and exposure information from both probands and their relatives. Moreover,
we anticipate joining the Collaborative Family Registries for Colorectal Cancer (Colon CFR)
and providing important data on Hispanic populations that would enable family-based
case-control studies of risk factors for CRC, with an emphasis on candidate genes in
selected carcinogenic pathways, genetic and epigenetic modifications. Furthermore,
information obtained from this proposal may serve to identify families that would be
informative for linkage studies to potentially map new genes, evaluate genotype-phenotype
correlations, gene-gene and gene-environmental interaction within the context of the Colon
CFR.