Know Cancer

forgot password

Familial Colorectal Cancer In Puerto Rico: A Feasibility Study

15 Years
Open (Enrolling)
Colorectal Cancer

Thank you

Trial Information

Familial Colorectal Cancer In Puerto Rico: A Feasibility Study

Data obtained from this two-year pilot study will serve as the foundation for our large,
island-wide, population-based, genetic-epidemiologic study of familial colorectal cancer in
Puerto Rico. Through this feasibility study, we will assess the feasibility: (1) of
recruiting colorectal cancer patients using the PR Central Cancer Registry, (2) of
evaluating family pedigrees and recruiting the relatives of probands (3) obtaining tumor,
blood, medical and exposure information from both probands and their relatives. Moreover,
we anticipate joining the Collaborative Family Registries for Colorectal Cancer (Colon CFR)
and providing important data on Hispanic populations that would enable family-based
case-control studies of risk factors for CRC, with an emphasis on candidate genes in
selected carcinogenic pathways, genetic and epigenetic modifications. Furthermore,
information obtained from this proposal may serve to identify families that would be
informative for linkage studies to potentially map new genes, evaluate genotype-phenotype
correlations, gene-gene and gene-environmental interaction within the context of the Colon

Inclusion Criteria

Inclusion criteria:

- patients with pathologic diagnosis of colorectal cancer (ICD codes 180-189,199,209)

- who are 15 years of age or older

Exclusion criteria:

-without previous history of colorectal cancer

Type of Study:


Study Design:

Observational Model: Family-Based, Time Perspective: Prospective

Outcome Measure:

We will recruit individuals with colorectal cancer with and without family history of CRC and their immediate family members and obtain the following: paraffin-embedded tumors blocks, blood samples, risk factor and food frequency questionnaires.

Outcome Time Frame:

5 years

Safety Issue:


Principal Investigator

Marcia R. Cruz-Correa, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Puerto Rico


United States: Institutional Review Board

Study ID:

R03CA130034 NCI



Start Date:

July 2007

Completion Date:

July 2015

Related Keywords:

  • Colorectal Cancer
  • Colorectal Cancer
  • Familial Colorectal Cancer
  • Genetics
  • Hispanics
  • Colorectal Neoplasms