A Natural History Study of HIV Acquired in Infancy or Childhood
Highly active antiretroviral therapy (HAART) has altered the natural history of HIV disease
The pediatric cohort in this country offers a tremendous opportunity to understand the
effect of HIV and ARTs on key developmental and maturational processes.
A thorough understanding of the impact of HIV and ARTs on these long-term processes is
extremely relevant as ART programs for HIV-infected children are being developed around the
To explore the clinical features and impact of HIV infection and antiretroviral therapy in
an HIV-infected pediatric cohort.
Known HIV disease and followed in the NCI pediatric HIV program as of December 2004, or
HIV-infected sibling of a participant.
Elgibility for the cardiac sub-study is expanded to include any person with HIV acquired in
infancy or young childhood who is older than 7 and meets other inclusion criteria.
Eligibility for cardiac sub-study will also include HIV uninfected subjects (18-30 years of
age) who will server as a control group.
Serial evaluations of pubertal development, bone mineralization, body composition and fat
distribution, hepatic, renal, and cardiac status, and behavioral, cognitive, and
Findings may be shared with the multicenter Pediatric HIV/AIDS Cohort Study and lead to more
intensive, focused substudies.
Rohan Hazra, M.D.
National Cancer Institute (NCI)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|