Inclusion Criteria

- INCLUSION CRITERIA: Recipient

Diagnosis of metastatic renal cell carcinoma, either clear cell type or non-clear cell
type. The diagnosis must be confirmed by the Laboratory of Pathology of NCI or Hackensack
(there will be no central pathology review).

The consent process will include a discussion of the potential role of high-dose IL-2
therapy prior to protocol enrollment. High-dose IL-2 therapy is not widely available, but
may be available on an NCI protocol (Dr. Yang) or through Dr. Alter for Hackensack
patients. IL-2 therapy may also be administered by any other qualified physician; the
Novartis web-site has a list of such physicians. For subjects who are deemed to be
eligible for high-dose IL-2 and elect to receive this therapy, such subjects must have
progressive disease post-IL-2 to enter this study; such subjects must also have received
and have had progressive disease after therapy with one of the agents listed below.

Subject must have progressive disease after therapy consisting of one of the following
FDA-approved agents: sorafenib, sunitib, or temsirolimus.

Patients 18 - 75 years of age. Subjects older than 75 will not be enrolled due to an
increased rate of transplant-related complications.

Must have consenting sibling matched at 6/6 HLA antigens (A, B, DR).

Patient or legal guardian must be able to give informed consent.

All previous therapy must be completed at least 2 weeks prior to study entry. Any grade 3
or 4 non-hematologic toxicity of any previous therapy must have resolved to grade 2 or
less.

Karnofsky performance status greater than or equal to 80%.

Life expectancy of at least 3 months.

Left ventricular ejection fraction greater than 40% (MUGA or echo) within 28 days of
enrollment.

DLCO greater than 50% of expected value (Hb corrected), obtained within 28 days of
enrollment.

Creatinine clearance greater than or equal to 40 ml/min. Creatinine clearance will be
determined by testing of a 24 hour urine collection and simultaneous serum creatinine
value. In previous studies, the creatine clearance of patients with metastatic renal cell
cancer who underwent nephrectomy was 53 plus or minus 19.

Serum total bilirubin less than 2.5 mg/dl, and serum ALT and AST values less than or equal
to 2.5 times the upper limit of normal. ALT and AST values above these levels may be
accepted (up to a maximum of 5 times the upper limit of normal), at the discretion of the
PI or study chairperson, if such elevations are thought to be due to liver involvement by
malignancy.

INCLUSION CRITERIA : Donor

Sibling who is 6/6 HLA-matched with recipient.

Ability to give informed consent.

Age 18 years to 80 years. Donors older than 80 will not be eligible due to potentially
increased complications from the donation procedure.

Adequate venous access for peripheral apheresis, or consent to use a temporary central
venous catheter for apheresis.

Donors must be HIV negative, hepatitis B surface antigen negative, and hepatitis C
antibody negative. This is to prevent the possible transmission of these infections to the
recipient. Donors with a history of hepatitis B or hepatitis C infections may be eligible.
However, eligibility determination of such patients will require a hepatology
consultation. The risk/benefit of the transplant and the possibility of transmitting
hepatitis will be discussed with the patient and eligibility will then be determined by
the principal investigator.

A donor who is lactating must substitute formula feeding for her infant during the period
of cytokine administration. Filgrastim may be secreted in human milk, although its
bioavailability from this source is not known. Limited clinical data suggest that
administration of filgrastim or to neonates is not associated with adverse outcomes.

EXCLUSION CRITERIA: Recipient

Active infection that is not responding to antimicrobial therapy.

Active CNS involvement by malignancy.

HIV infection. There is theoretical concern that the degree of immune suppression
associated with the treatment may result in progression of HIV infection.

Chronic active hepatitis B. Patient may be hepatitis B core antibody positive. For
patients with concomitant positive hepatitis B surface antigen, patient will require a
hepatology consultation. The risk/benefit profile of transplant and hepatitis B will be
discussed with the patient and eligibility determined by the principal investigator and
protocol chairperson.

Hepatitis C infection. Patient may have hepatitis C infection. However, each patient will
require a hepatology consultation. The risk/benefit profile of transplant and hepatitis C
will be discussed with the patient and eligibility determined by the principal
investigator and protocol chairperson.

Pregnant or lactating. Patients of childbearing potential must use an effective method of
contraception from the time of study entry to at least one year post-transplant; effective
methods include intrauterine device (IUD), hormonal (birth control pills, injections, or
implants), tubal ligation/hysterectomy, partner's vasectomy, or barrier methods (condom,
diaphragm, or cervical cap). Males on the protocol, and their partners of child-bearing
potential, must also use an effective form of contraception at study entry and for one
year post-transplant. The effects of the chemotherapy, the subsequent transplant, and the
medications used after the transplant are highly likely to be harmful to a fetus. The
effects upon breast milk are also unknown and may be harmful to the infant; therefore,
women should not breastfeed during the interval from study entry to one year
post-transplant.

History of psychiatric disorder which may compromise compliance with transplant protocol,
or which does not allow for appropriate informed consent (as determined by principal
investigator or study chairman).

EXCLUSION CRITERIA: Donor

History of psychiatric disorder which may compromise compliance with transplant protocol,
or which does not allow for appropriate informed consent.

History of hypertension that is not controlled by medication, stroke, or severe heart
disease. Individuals with symptomatic angina will be considered to have severe heart
disease and will not be eligible to be a donor.

No other medical contraindications to stem cell donation (i.e. severe atherosclerosis,
autoimmune disease, iritis or episcleritis, deep venous thrombosis, cerebrovascular
accident). Patients with a history of coronary artery bypass grafting or angioplasty will
receive a cardiology evaluation and be considered on a case-by-case basis.

History of prior malignancy. However, cancer survivors who have undergone potentially
curative therapy may be considered for stem cell donation on a case-by-case basis. The
risk/benefit of the transplant and the possibility of transmitting viable tumor cells at
the time of transplantation will be discussed with the patient.

Donors must not be pregnant. The effects of cytokine therapy on a fetus are unknown.
Donors of childbearing potential must use an effective method of contraception from the
time of study entry until at least one year post-transplant.

Anemia (Hb less than 11 gm/dl) or thrombocytopenia (platelets less than 100,000 per
microliter).