Inclusion Criteria

Inclusion criteria:

1. Subjects with a histological or cytological diagnosis of solid tumors or gastric
cancer.

2. Subjects who have progressed after treatment with approved therapies or for whom
there are no standard effective therapies available.

3. Subjects with adequate organ function.

4. Patients who have no carryover of effect from prior therapy or no adverse drug
reactions (excluding alopecia) that may affect the safety evaluation of the
investigational drug.

5. Subjects with Performance Status (PS) 0-1 established by Eastern Cooperative Oncology
Group (ECOG).

Exclusion criteria:

1. Subjects who have brain metastases with clinical symptoms or which requires
treatment.

2. Subjects with the serious complications or disease history.

3. Subjects who cannot take oral medication.

4. Subjects who need continuous use of drugs or foods that strongly inhibit or induce
CYP3A4/5 or CYP2D6 during the study period.

5. Female subjects who are pregnant or breast-feeding.