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Collection of Bone Marrow and Peripheral Blood for Testing of Notch-induced Natural Killer Cell Activity


N/A
N/A
N/A
Not Enrolling
Both
Leukemia, Multiple Myeloma and Plasma Cell Neoplasm

Thank you

Trial Information

Collection of Bone Marrow and Peripheral Blood for Testing of Notch-induced Natural Killer Cell Activity


OBJECTIVES:

- To collect normal and malignant cells in bone marrow and peripheral blood samples from
patients with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous
leukemia, or multiple myeloma and from patients with no malignancy to use as target
cells in cytotoxicity assays.

- To collect information about HLA type and immunophenotype of malignant cells as
determined by clinical flow cytometry.

OUTLINE: Bone marrow aspirates and/or peripheral blood samples are collected and used as
target cells in standard cytotoxicity assays, with notch-induced natural killer (N-NK) cells
as the effector cells, to determine whether N-NK cells are capable of killing malignant
cells and/or non-malignant cells. Receptor-blocking antibodies may be added to determine
which NK cell receptors are responsible for malignant cell recognition and killing.

Information about HLA type and immunophenotype of the malignant cells is collected from the
patient's medical record.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets one of the following criteria:

- No evidence of malignancy

- Diagnosis of one of the following:

- Acute myeloid leukemia

- Acute lymphoblastic leukemia

- Chronic myelogenous leukemia

- Multiple myeloma

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Collection of normal and malignant cells to use as target cells in cytotoxicity assays

Outcome Time Frame:

We anticipate collecting approximately 30 samples in total, over a 1-2 year period.

Safety Issue:

No

Principal Investigator

Rose Beck, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

CASE2Z08

NCT ID:

NCT00918658

Start Date:

April 2008

Completion Date:

March 2011

Related Keywords:

  • Leukemia
  • Multiple Myeloma and Plasma Cell Neoplasm
  • childhood chronic myelogenous leukemia
  • chronic myelogenous leukemia
  • adult acute lymphoblastic leukemia
  • childhood acute lymphoblastic leukemia
  • adult acute myeloid leukemia
  • childhood acute myeloid leukemia/other myeloid malignancies
  • multiple myeloma
  • Neoplasms
  • Leukemia
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma

Name

Location

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer CenterCleveland, Ohio  44106-5065