Phase II Trial of Stereotactic Body Radiation Therapy for Unresectable Liver Metastases From Colorectal Carcinoma
From July 2003 to May 2007, over 50 patients with liver metastases participated in two
studies at Princess Margaret Hospital (PMH) designed to determine the safety of treating
liver metastases with SBRT. These studies have shown that SBRT can be delivered safely to
the majority of patients with liver metastases. The treated tumour was controlled (shrank or
remained the same size) in 74% of patients at one year following treatment. The median
survival of patients was 16 months (i.e.half of patients survived longer and half shorter
than 16 months). This survival rate is better than that expected in patients whose tumours
grew bigger even though they were treated with chemotherapy. Supportive care only (no
treatment other than care to make you feel better) in these patients is associated with a
median survival rate of 6-12 months. We expect that the benefits of SBRT in this study will
be similar to those observed in our initial studies.
Interventional
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Determine one year local progression free rate, defined as lack of progression within the irradiated volume, using RECIST criteria.
5 years
No
Laura Dawson, MD
Principal Investigator
University Health Network, Princess Margaret Hospital
Canada: Ethics Review Committee
UHN REB 07-0348-C
NCT00914615
August 2007
August 2015
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