Inclusion Criteria

Inclusion criteria:

1. Patients must have a histologically or cytologically confirmed advanced solid tumor
that has progressed following standard therapy or for which no standard therapy
exists (including surgery or radiation therapy). Patients with measurable tumors
according to RECIST are desirable but not essential.

2. Patients must be aged 18 years or older.

3. Patients must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of
0,1, or 2.

4. Patients must have adequate renal function as evidenced by serum creatinine ≤135 µM/L
(≤1.5 mg/dL) or creatinine clearance >= 40 mL/minute (min).

5. Patients must have adequate bone marrow function as evidenced by absolute neutrophil
count (ANC) >= 1.5 x 10^9/L and platelet count >= 100 x 10^9/L.

6. Patients must have adequate hepatic function as evidenced by bilirubin ≤ 1.5 times
the upper limit of normal (ULN) and alkaline phosphatase, alanine aminotransferase
(ALT), and aspartate aminotransferase (AST) ≤ 3 x ULN (in the case of liver
metastases ≤ 5 x ULN), unless there are bone metastases, in which case liver specific
alkaline phosphatase must be separated from the total and used to assess the liver
function instead of the total alkaline phosphatase.

7. Resolution of all chemotherapy or radiation-related toxicities to Grade 1 severity or
below, except for stable sensory neuropathy ≤ Grade 2 and alopecia.

8. Patients must be willing and able to comply with the study protocol for the duration
of the study.

9. Patients must give written informed consent prior to any study-specific screening
procedures with the understanding that the patient may withdraw consent at any time
without prejudice.

Exclusion Criteria:

1. Patients who have received any of the following treatments within the specified
period before treatment start:

- chemotherapy, radiation, or biological therapy within three weeks

- hormonal therapy within one week

- any investigational drug within 4 weeks

- systemic unconventional or alternative therapies including, but not limited to,
herbal remedies within 4 weeks

2. Have had radiation therapy encompassing > 30% of marrow.

3. Have received prior treatment with mitomycin C or nitrosourea.

4. Have had major surgery within 4 weeks before starting study treatment

5. Patients with pulmonary lymphangitic involvement that results in pulmonary
dysfunction requiring active treatment, including the use of oxygen.

6. Patients with brain or subdural metastases are not eligible, unless they have
completed local therapy and have discontinued the use of corticosteroids for this
indication for at least 4 weeks before starting treatment in this study. Any signs
(e.g., radiologic) and/or symptoms of brain metastases must be stable for at least 4
weeks.

7. Patients with meningeal carcinomatosis.

8. Patients who are receiving anti-coagulant therapy with warfarin or related compounds,
other than for line patency, and cannot be changed to heparin-based therapy, are not
eligible. If a patient is to continue on mini-dose warfarin, then the prothrombin
time (PT) or international normalized ratio (INR) must be closely monitored.

9. Women who are pregnant or breast-feeding; women of childbearing potential with either
a positive pregnancy test at screening or no pregnancy test; women of childbearing
potential unless (1) surgically sterile or (2) using adequate measures of
contraception in the opinion of the Investigator. Peri-menopausal women must be
amenorrheic for at least 12 months to be considered of non-childbearing potential.

10. Patients with severe/uncontrolled intercurrent illness/infection.

11. Significant cardiovascular impairment (history of congestive heart failure > New York
Heart Association (NYHA) grade II, unstable angina or myocardial infarction within
the past 6 months, or serious cardiac arrhythmia).

12. Patients with organ allografts requiring immunosuppression.

13. Patients with known positive HIV status.

14. Patients with pre-existing neuropathy > Grade 2.

15. Patients with a hypersensitivity to halichondrin B and/or halichondrin B chemical
derivative.

16. Patients who participated in a prior eribulin clinical trial, whether or not they
received eribulin (E7389).

17. Patients with other significant disease or disorders that, in the Investigator's
opinion, would exclude the patient from the study.