Inclusion Criteria:

- Male or female recipients of a de novo kidney transplant, aged above 18 years

- Women of childbearing potential must have a negative serum or urine pregnancy test
with sensitivity equal to at least 50 mIU/ml

- Patients must be capable of understanding the purpose and risks of the study, and
must sign an informed consent form

Exclusion Criteria:

- Multiple organ transplantation (e.g., Kidney-pancreas, kidney-heart, kidney-
liver,...)

- Transplantation of a patient who got another organ transplant previously

- Recipients of a HLA-identical living-related renal transplant

- Patients with PRA > 30%, patients who have lost a first graft from rejection within
two years after transplantation, and African European patients.

- Patients with primary renal disease at risk for recurrence: FSGS, MPGN, HUS

- Pregnant or lactating women

- WBC < 2.5 x 109/l (IU), platelet count < 100 x 109/l (IU), or Hb < 6 g/dl at the time
of entry into the study

- Active peptic ulcer

- Severe diarrhea or other gastrointestinal disorder, which might interfere with their
ability to absorb oral medication, including diabetic patients with previously
diagnosed diabetic gastroenteropathy

- Known HIV-1 or HTLV-1 positive tests

- The use of investigational drugs or other immunosuppressive drugs, as those specified
in this protocol

- Patients receiving bile acid sequestrants

- Psychological illness or condition, interfering with the patient's compliance or
ability to understand the requirements of the study