Inclusion Criteria:

1. Advanced stages of thyroid malignant tumors (stage III and VI)

2. At least one target tumor can be injected with study drug, the largest diameter
greater than 2 cm

3. Histologically confirmed Oral and Maxillofacial malignant tumors

4. No prior chemotherapy, radiotherapy or biological tumor therapy in 2 weeks

5. Age: 18-85 years old

6. Expected to survive more 12 weeks

7. ECOG:0-2

8. Neutrophils≥1.5×109/L,Platelet≥ 80×109/L, Hb≥80g/L, bilitubin≤2mg/dl,ALT and AST
≤2×institutional upper limit of normal, Cr ≤1.5×institutional upper limit of
normal,coagulation tests (PTT and INR) within normal range

9. Subject provided signed informed consent -

Exclusion Criteria:

1. Hypersensitive to study drug

2. Tumor(s) locate very close to important blood vessels and nerves, which affect
injection

3. With a coagulation and bleeding disorder

4. With uncontrolled, intercurrent illness including but limited to symptomatic
neurological illness, symptomatic congestive heart failure, unstable angina pectoris,
significant pulmonary disease or hypoxia, or psychiatric illness

5. Local infection close to injection site or systemic infection

6. Pregnant or lactating

7. Principle investigator consider not suitable