Blood and Tissue Analysis in Surgery Branch NCI From Stored Samples
N/A
N/A
Both
Kidney Cancer, Melanoma (Skin), Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
Trial Information
Blood and Tissue Analysis in Surgery Branch NCI From Stored Samples
OBJECTIVES:
- Conduct laboratory studies on the function and structure of patients' cells, cell
products, or serum components in relation to the cellular immune response generated
against their cancer.
OUTLINE: Blood and/or tissue samples collected on NCI Surgery Branch protocols are analyzed
for function and/or structure of patients' cells, cell products, or serum components in
relation to the cellular immune response generated against their cancer. Samples may be
evaluated for antigen expression by tumor cells, antitumor reactivity of lymphocytes grown
from biopsies, immunological monitoring of cell function, DNA and RNA extraction for PCR
analysis of T cell receptor and vector copy number estimation, quantifying T-cell reactivity
by fluorescence-activated cell sorter analysis using tetramer staining, cytokine release by
bulk peripheral blood lymphocytes (with or without peptide stimulation), and other
experimental studies, such as cytolysis.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Tissue and/or blood samples stored at the NCI Surgery Branch from one of the
following protocols (or newly terminated protocols):
- NCI- 86-C-0046
- NCI-86-C-0183
- NCI-90-C-0085
- NCI-90-C-0186
- NCI-91-C-0094
- NCI-91-C-0199
- NCI-93-C-0187
- NCI-95-C-0078
- NCI-95-C-0079
- NCI-95-C-0145
- NCI-96-C-0120
- NCI-96-C-0121
- NCI-97-C-0019
- NCI-98-C-0022
- NCI-98-C-0086
- NCI-98-C-0159
- NCI-99-C-0018
- NCI-99-C-0044
- NCI-99-C-0092
- NCI-99-C-0095
- NCI-99-C-0159
- NCI-00-C-0182
- NCI-00-C-0216
- NCI-01-C-0032
- NCI-01-C-0193
- NCI-02-C-0106H
- NCI-03-C-0080
- NCI-03-C-0109
- NCI-03-C-0299
- NCI-04-C-0134
- NCI-04-C-0235
- NCI-03-C-0094
- NCI-04-C-0114
- NCI-04-C-0083
- NCI-05-C-0194
- NCI-06-C-0137
- NCI-04-C-0152
- NCI-04-C-0259
- NCI-04-C-0288
- NCI-06-C-0136
- NCI-06-C-0169
- NCI-05-C-0141
- NCI-08-C-0155
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Cellular immune response
Safety Issue:
No
Principal Investigator
Steven A. Rosenberg, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
NCI - Surgery Branch
Authority:
United States: Federal Government
Study ID:
CDR0000590280
NCT ID:
NCT00900926
Start Date:
January 2007
Completion Date:
January 2007
Related Keywords:
- Kidney Cancer
- Melanoma (Skin)
- Unspecified Adult Solid Tumor, Protocol Specific
- Unspecified Childhood Solid Tumor, Protocol Specific
- unspecified adult solid tumor, protocol specific
- unspecified childhood solid tumor, protocol specific
- renal cell carcinoma
- melanoma
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Melanoma
- Neoplasms
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