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Evaluation of Cyclooxygenase-2 Expression in Normal Cervix, Cervical Intraepithelial Neoplasia and Early Invasive Squamous Cell Carcinoma With Correlation to Parameters of Invasion and Angiogenesis


N/A
18 Years
N/A
Not Enrolling
Female
Cervical Cancer, Precancerous Condition

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Trial Information

Evaluation of Cyclooxygenase-2 Expression in Normal Cervix, Cervical Intraepithelial Neoplasia and Early Invasive Squamous Cell Carcinoma With Correlation to Parameters of Invasion and Angiogenesis


OBJECTIVES:

- Determine cyclooxygenase-2 (COX-2) levels in biopsy or surgical specimens from patients
with normal cervical epithelium, cervical intraepithelial neoplasia, or microinvasive
squamous cell carcinoma of the cervix.

- Correlate COX-2 levels with histological diagnosis and parameters of invasion (i.e.,
matrix metalloproteinase, microvessel count, and VEGF).

OUTLINE: Paraffin-embedded tissue samples are analyzed by immunohistochemistry for
evaluation of cyclooxygenase-2 levels, microvessel count, and matrix metalloproteinase and
VEGF expression.

Medical data for study analysis is obtained by retrospective review of patient charts.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Underwent hysterectomy with removal of a normal cervix for diagnosis unrelated
to cancer or cervical dysplasia

- Underwent cervical biopsy or removal of cervical tissue and diagnosed with
cervical intraepithelial neoplasia (CIN) grades 1-3

- Underwent cervical biopsy and diagnosed with microinvasive squamous cell
carcinoma of the cervix

- Paraffin-embedded tissue samples of normal cervical epithelium, CIN, or microinvasive
squamous cell carcinoma of the cervix must be available for examination

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Cyclooxygenase-2 (COX-2) levels in cervical intraepithelial neoplasia (CIN)

Outcome Time Frame:

day 1

Safety Issue:

No

Principal Investigator

Brigitte E. Miller, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Comprehensive Cancer Center of Wake Forest University

Authority:

United States: Institutional Review Board

Study ID:

CDR0000550067

NCT ID:

NCT00900081

Start Date:

May 2003

Completion Date:

Related Keywords:

  • Cervical Cancer
  • Precancerous Condition
  • cervical squamous cell carcinoma
  • stage IA cervical cancer
  • stage 0 cervical cancer
  • cervical intraepithelial neoplasia grade 1
  • cervical intraepithelial neoplasia grade 2
  • cervical intraepithelial neoplasia grade 3
  • Neoplasms
  • Carcinoma, Squamous Cell
  • Uterine Cervical Neoplasms
  • Precancerous Conditions
  • Cervical Intraepithelial Neoplasia
  • Carcinoma in Situ

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