Dysregulation of Hematopoiesis in Fanconi Anemia
- Identify the specific molecular function of the Fanconi anemia (FA) complementing gene
products in hematopoietic progenitor cells from patients with FA.
- Identify functional defects in hematopoietic stromal cells from patients with FA.
OUTLINE: Peripheral blood mononuclear leukocytes, skin fibroblasts, and marrow fibroblasts
are collected for loss-of-function and gain-of-function analysis related to the Fanconi
anemia complementing gene.
Observational Model: Cohort, Time Perspective: Prospective
Loss of function analyses
Duration of the study
Grover C. Bagby, MD
OHSU Knight Cancer Institute
United States: Federal Government
|Knight Cancer Institute at Oregon Health and Science University||Portland, Oregon 97239-3098|