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Dysregulation of Hematopoiesis in Fanconi Anemia


N/A
1 Year
55 Years
Open (Enrolling)
Both
Chronic Myeloproliferative Disorders, Fanconi Anemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic/Myeloproliferative Neoplasms

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Trial Information

Dysregulation of Hematopoiesis in Fanconi Anemia


OBJECTIVES:

- Identify the specific molecular function of the Fanconi anemia (FA) complementing gene
products in hematopoietic progenitor cells from patients with FA.

- Identify functional defects in hematopoietic stromal cells from patients with FA.

OUTLINE: Peripheral blood mononuclear leukocytes, skin fibroblasts, and marrow fibroblasts
are collected for loss-of-function and gain-of-function analysis related to the Fanconi
anemia complementing gene.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Diagnosis of one of the following:

- Fanconi's anemia requiring bone marrow biopsy as part of standard care
(adults and children)

- Myeloproliferative disorder or myeloma (adults)

- Healthy volunteer, meeting 1 of the following criteria:

- Over 18 years of age

- Bone marrow transplant donor (children)

PATIENT CHARACTERISTICS:

- Hemoglobin > 13 g/dL

- WBC > 4,000/mm³

- Platelet count > 150,000/mm³

- No clinical signs or symptoms of acute or subacute infections (viral, bacterial, or
fungal)

- No known blood abnormality (healthy volunteers)

- No allergies to lidocaine or xylocaine

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Loss of function analyses

Outcome Time Frame:

Duration of the study

Safety Issue:

No

Principal Investigator

Grover C. Bagby, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

OHSU Knight Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000445231

NCT ID:

NCT00900055

Start Date:

June 1975

Completion Date:

Related Keywords:

  • Chronic Myeloproliferative Disorders
  • Fanconi Anemia
  • Multiple Myeloma and Plasma Cell Neoplasm
  • Myelodysplastic/Myeloproliferative Neoplasms
  • Fanconi anemia
  • multiple myeloma and other plasma cell neoplasms
  • chronic myeloproliferative disorders
  • myelodysplastic/myeloproliferative neoplasms
  • Anemia
  • Neoplasms
  • Fanconi Anemia
  • Fanconi Syndrome
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma
  • Myeloproliferative Disorders
  • Myelodysplastic-Myeloproliferative Diseases

Name

Location
Knight Cancer Institute at Oregon Health and Science University Portland, Oregon  97239-3098