Reproducibility of Serum Sex Steroid Measurement: A Proof of Performance Study
20 Years
75 Years
Both
Healthy, no Evidence of Disease
Trial Information
Reproducibility of Serum Sex Steroid Measurement: A Proof of Performance Study
OBJECTIVES:
- Evaluate reproducibility of sex steroid assays, including testosterone,
dihydrotestosterone, androstenedione, estrone, estradiol, androstenediol, and
dehydroepiandrosterone (DHEA) by gas chromatography-mass spectrometry (GC-MS) and
androstenediol glucuronide, androsterone glucuronide, DHEA sulfate, and estrone sulfate
by liquid chromatography (LC)-MS-MS.
- Evaluate the reproducibility of the measurement of these steroids and metabolites by
radioimmunoassay (RIA).
- Compare the assay results of GC-MS and LC-MS-MS to those of RIA.
OUTLINE: Participants undergo blood collection for laboratory analysis. Samples are analyzed
by gas chromatography-mass spectrometry (MS), liquid chromatography-MS-MS, and
radioimmunoassay to assess the reproducibility of these assays for measuring sex steroids.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Participants must meet 1 of the following criteria:
- Healthy men 50 to 65 years old; employed by Westat or their related family and
friends
- Premenopausal women 20 to 40 years old
- Postmenopausal women 55 to 75 years old
PATIENT CHARACTERISTICS:
- See Disease Characteristics
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Reproducibility of sex steroid assays including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) -MS-MS
Safety Issue:
No
Principal Investigator
Ann Hsing, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
National Cancer Institute (NCI)
Authority:
United States: Federal Government
Study ID:
CDR0000566368
NCT ID:
NCT00899925
Start Date:
Completion Date:
Related Keywords:
- Healthy, no Evidence of Disease
- healthy, no evidence of disease
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