Molecular Mechanisms of OSCC Tumor Invasion
- To test preliminary data from node-positive oral squamous cell carcinoma (OSCC)
signatures for their ability to predict lymph-positive primaries using a cohort of OSCC
- To perform lymph node prediction using sentinel lymph node-biopsied primaries.
- To validate the preliminary data node-positive OSCC signature and test its ability to
predict nodal status.
OUTLINE: Patient tissue samples are screened using polymerase chain reaction (PCR) for human
papilloma virus-specific primers. Samples are analyzed to identify a nodal-metastasis
signature for oral squamous cell carcinoma. Samples also undergo microarray analysis to
quantify expression levels for targeted genes. Initial data analysis is performed using
Affymetrix® Microarray Suite 5.0 to quantify expression levels for targeted genes.
Predictive ability of node-positive OSCC signature
Barry L. Ziober, PhD
Abramson Cancer Center of the University of Pennsylvania
United States: Federal Government