Molecular Mechanisms of OSCC Tumor Invasion
N/A
N/A
Both
Head and Neck Cancer
Trial Information
Molecular Mechanisms of OSCC Tumor Invasion
OBJECTIVES:
- To test preliminary data from node-positive oral squamous cell carcinoma (OSCC)
signatures for their ability to predict lymph-positive primaries using a cohort of OSCC
tumors.
- To perform lymph node prediction using sentinel lymph node-biopsied primaries.
- To validate the preliminary data node-positive OSCC signature and test its ability to
predict nodal status.
OUTLINE: Patient tissue samples are screened using polymerase chain reaction (PCR) for human
papilloma virus-specific primers. Samples are analyzed to identify a nodal-metastasis
signature for oral squamous cell carcinoma. Samples also undergo microarray analysis to
quantify expression levels for targeted genes. Initial data analysis is performed using
Affymetrix® Microarray Suite 5.0 to quantify expression levels for targeted genes.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Have a primary tumor specimen banked by the American College of Surgeons Oncology
Group (ACOSOG) as part of clinical trial ACOSOG-Z0360
- All tumor specimens are squamous cell carcinomas of the tongue, floor of the
mouth, or gingiva
- All patients have undergone neck dissections
- Pathologically confirmed nodal stage (negative or positive)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Predictive ability of node-positive OSCC signature
Safety Issue:
No
Principal Investigator
Barry L. Ziober, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
Abramson Cancer Center of the University of Pennsylvania
Authority:
United States: Federal Government
Study ID:
CDR0000589332
NCT ID:
NCT00899704
Start Date:
March 2008
Completion Date:
Related Keywords:
- Head and Neck Cancer
- stage I squamous cell carcinoma of the lip and oral cavity
- stage II squamous cell carcinoma of the lip and oral cavity
- tongue cancer
- Head and Neck Neoplasms
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