Proteases in Prostate Cancer Bone Metastasis
- Examine the roles of proteases and protease-associated molecules in bone metastases in
patients with metastatic prostate cancer.
OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are
analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography
and/or Western blot analysis, and gene profiling analysis in order to visualize and
quantitate protease or protease-related levels.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Expression and activity of proteases and related molecules
Michael L. Cher, MD
Barbara Ann Karmanos Cancer Institute
United States: Federal Government
|Barbara Ann Karmanos Cancer Institute||Detroit, Michigan 48201|