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Proteases in Prostate Cancer Bone Metastasis


N/A
40 Years
N/A
Not Enrolling
Male
Anemia, Metastatic Cancer, Myelodysplastic Syndromes, Precancerous Condition, Prostate Cancer

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Trial Information

Proteases in Prostate Cancer Bone Metastasis


OBJECTIVES:

- Examine the roles of proteases and protease-associated molecules in bone metastases in
patients with metastatic prostate cancer.

OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are
analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography
and/or Western blot analysis, and gene profiling analysis in order to visualize and
quantitate protease or protease-related levels.

PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Diagnosis of metastatic prostate cancer

- Patients with documented bone metastases on radiologic imaging studies must
undergo bone marrow biopsy

- Male patients ≥ 50 years of age without cancer who are scheduled to undergo bone
biopsy for other clinically indicated reasons, including any of the following:

- Myelodysplasia

- Anemia

- Monoclonal gammopathy of undetermined significance

- Male or female patients ≥ 40 years of age without metastatic bone cancer who are
scheduled to undergo an orthopedic procedure involving removal of bone specimen

PATIENT CHARACTERISTICS:

- See Disease Characteristics

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Expression and activity of proteases and related molecules

Safety Issue:

No

Principal Investigator

Michael L. Cher, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Barbara Ann Karmanos Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000483773

NCT ID:

NCT00899665

Start Date:

July 2001

Completion Date:

January 2008

Related Keywords:

  • Anemia
  • Metastatic Cancer
  • Myelodysplastic Syndromes
  • Precancerous Condition
  • Prostate Cancer
  • stage IV prostate cancer
  • bone metastases
  • anemia
  • monoclonal gammopathy of undetermined significance
  • de novo myelodysplastic syndromes
  • previously treated myelodysplastic syndromes
  • secondary myelodysplastic syndromes
  • Anemia
  • Myelodysplastic Syndromes
  • Preleukemia
  • Neoplasm Metastasis
  • Neoplasms
  • Neoplasms, Second Primary
  • Precancerous Conditions
  • Prostatic Neoplasms

Name

Location
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201