Breast Tissue/Body Fluids Repository
- To create a database that includes environmental, demographic, phenotypic, clinical,
pathologic, genetic, and prognostic factors in large cohorts of women with different
stages of breast cancer.
- To create a tissue repository that contains DNA, RNA, or protein from tumor tissue or
normal tissue, peripheral blood lymphocytes, and plasma that are linked to frozen
and/or paraffin-embedded pathology specimens.
OUTLINE: Patients undergo tumor tissue and normal tissue sample collection at the time of
medically indicated surgery or biopsy. Archival tissue may also be collected. Patients and
normal volunteers also undergo blood and urine sample collection. A repository of tissue,
blood, and urine samples will be established to facilitate current and future research
studies to learn about the biologic features of breast cancer development and progression.
Research studies may include molecular pathology studies and gene and protein expression
Patients' medical records are reviewed over approximately 5 years to determine if the test
results are associated with health status. Patients do not receive the results of individual
Observational Model: Cohort, Time Perspective: Prospective
Creation of a tissue repository that contains DNA, RNA, or protein from tumor tissue or normal tissue, peripheral blood lymphocytes, and plasma that are linked to frozen and/or paraffin-embedded pathology specimens
A. Bapsi Chakravarthy, MD
Vanderbilt-Ingram Cancer Center
United States: Vanderbilt University Human Research Protection Program
VICC BRE 03103
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|