Biomarkers of Survival in HNSCC
N/A
N/A
Both
Head and Neck Cancer
Trial Information
Biomarkers of Survival in HNSCC
OBJECTIVES:
- Determine if gene expression patterns that correlate with treatment response and
survival can be identified using DNA microarrays in patients with newly diagnosed head
and neck squamous cell carcinoma (HNSCC) treated with carboplatin, paclitaxel, and
radiotherapy.
- Determine if protein expression patterns that correlate with treatment response and
survival in HNSCC can be identified using matrix-assisted laser desorption
ionization-time-of-flight mass spectrometry (MALDI-TOFMS).
- Determine if the molecular signature of human papilloma virus-16 infection can be
determined using DNA microarray and MALDI-TOFMS and correlate with gene and protein
expression, treatment response, and survival.
OUTLINE: Tumor tissue samples are analyzed by DNA microarray analysis and validated by
quantitative reverse transcription-polymerase chain reaction (PCR). Protein and gene
expression patterns are analyzed by laser desorption ionization-time-of-flight mass
spectrometry, high performance liquid chromatography, liquid chromatography-tandem mass
spectrometry, and PCR. Samples are also analyzed by tissue microarray and
immunohistochemistry.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Newly diagnosed head and neck squamous cell carcinoma
- Stage III-IV disease
- Scheduled for pan-endoscopy
- Tumor tissue available from patients treated with carboplatin, paclitaxel, and
radiotherapy on protocol VU-VICC-HN-0356
PATIENT CHARACTERISTICS:
- Able to speak English
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Survival
Outcome Time Frame:
at expiration of last patient enrolled
Safety Issue:
No
Principal Investigator
Barbara Murphy, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Food and Drug Administration
Study ID:
VICC HN 0392
NCT ID:
NCT00898430
Start Date:
November 2003
Completion Date:
February 2011
Related Keywords:
- Head and Neck Cancer
- stage III squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the larynx
- stage III verrucous carcinoma of the larynx
- stage IV squamous cell carcinoma of the larynx
- stage IV verrucous carcinoma of the larynx
- stage III squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- stage III verrucous carcinoma of the oral cavity
- stage IV verrucous carcinoma of the oral cavity
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- untreated metastatic squamous neck cancer with occult primary
- stage III squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- stage III squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- salivary gland squamous cell carcinoma
- stage III salivary gland cancer
- stage IV salivary gland cancer
- Head and Neck Neoplasms
Name | Location |
|---|---|
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville, Tennessee 37064 |
| Vanderbilt-Ingram Cancer Center at Franklin | Nashville, Tennessee 37064 |
