Trial Information

Morphometric Diagnosis of Atypical Glandular Lesions Using a Conventional Pap Smear From GOG-0171 Patients (Enrolled by GOG-Japan) With a Cytologic Diagnosis of Atypical Glandular Cells of Unspecified Significance (AGUS)

OBJECTIVES:

Primary

- To determine the diagnostic accuracy of using previously reported morphometric criteria
for chromatin distribution, shortest distance between nuclei, and/or the ratio of
nucleoli area to nucleus area in a conventional Pap smear from patients with a
cytologic diagnosis of atypical glandular cells of unspecified significance (AGUS) to
predict the presence of significant glandular lesions (i.e., adenocarcinoma in situ
[AIS] or invasive cancer) and/or squamous lesions (i.e., cervical intraepithelial
neoplasia [CIN2 or CIN3]) of the cervix.

Secondary

- To optimize the diagnostic accuracy of using chromatin distribution, shortest distance
between nuclei, and/or the ratio of nucleoli area to nucleus area in a conventional Pap
smear from patients with a cytologic diagnosis of AGUS to predict the presence of
significant glandular lesions (i.e., AIS or invasive cancer) and/or squamous lesions
(i.e., CIN2 or CIN3) of the cervix.

OUTLINE: Previously collected slides from Pap smears of patients enrolled on clinical trial
GOG-171 are assessed for nuclear chromatin distribution, the shortest distances between the
central points of neighboring cell nuclei, and nucleoli area/nucleus area (N/N) ratio via
morphometric analysis.