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Proposal for Combining ECOG Myeloma Trial SNP Data


N/A
18 Years
N/A
Not Enrolling
Both
Multiple Myeloma and Plasma Cell Neoplasm

Thank you

Trial Information

Proposal for Combining ECOG Myeloma Trial SNP Data


OBJECTIVES:

- Determine whether there is an increased frequency of 1 or more polymorphic alleles that
are associated with clinical endpoints using custom myeloma single nucleotide
polymorphism (SNP) chip analysis of banked DNA samples from patients with multiple
myeloma.

- Determine SNPs associated with toxicities caused, not by variations in tumor cell
genetics, but by individual genetic variations affecting drug activation, distribution,
metabolism, and export (ADME).

- Determine SNPs associated with response, influenced by the same ADME.

- Determine SNPs associated with bone disease (as a variable) among patients with
multiple myeloma.

- Determine SNPs associated with epidemiology (i.e., risk factors for the development of
multiple myeloma).

OUTLINE: This is a retrospective, multicenter study.

Banked DNA samples are analyzed using a custom single nucleotide polymorphism (SNP) chip to
assess approximately 3,590 SNPs from 1,061 genes that are associated with myeloma growth and
response.

PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of multiple myeloma

- DNA samples banked from other ECOG studies (and other clinical trial groups [e.g.,
SWOG and MRC])

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Increased frequency of ≥1 polymorphic alleles associated with clinical endpoints using custom myeloma SNP chip analysis of banked DNA samples from patients with multiple myeloma

Safety Issue:

No

Principal Investigator

Brian Van Ness

Investigator Role:

Study Chair

Investigator Affiliation:

Masonic Cancer Center, University of Minnesota

Authority:

Unspecified

Study ID:

CDR0000495284

NCT ID:

NCT00898040

Start Date:

Completion Date:

Related Keywords:

  • Multiple Myeloma and Plasma Cell Neoplasm
  • stage I multiple myeloma
  • stage II multiple myeloma
  • stage III multiple myeloma
  • refractory multiple myeloma
  • Neoplasms
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma

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