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Developing Predictive Markers of Therapeutic Response in Pancreatic Cancer


N/A
N/A
N/A
Not Enrolling
Both
Pancreatic Cancer

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Trial Information

Developing Predictive Markers of Therapeutic Response in Pancreatic Cancer


OBJECTIVES:

- To determine if a method of extracting and identifying biomarkers (i.e., secreted
cytokines and growth factors) from tissues of the quantity obtained from typical biopsy
can now be applied in the setting of pancreatic cancer

- To correlate pre-treatment biomarkers with recurrence, overall survival, and tumor
response to radiotherapy and chemotherapy in patients with pancreatic cancer.

OUTLINE: Tumor tissue specimens are obtained from the Vanderbilt Ingram Cancer Center Human
Tissue Acquisition Core and analyzed for biomarkers (e.g., integrity of DNA repair pathways
as analyzed by Rad51 and phosphorylated DNA-PK foci formation). The biomarkers are
correlated with clinical outcomes (recurrence, overall survival, and tumor response to
treatment).

Patients are followed for recurrence, relapse, and death from disease.

Inclusion Criteria


Inclusion criteria

- Diagnosis of pancreatic cancer

- Excess tissue collected at the time of routine surgery for pancreatic cancer must be
available for analysis

Exclusion criteria

- None known

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Determination if a method of extracting and identifying biomarkers from tissues of the quantity obtained from typical biopsy can be applied in the setting of pancreatic cancer

Outcome Time Frame:

1 year following final patient data

Safety Issue:

No

Principal Investigator

A. Bapsi Chakravarthy, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

VICC GI 0666

NCT ID:

NCT00897832

Start Date:

January 2007

Completion Date:

December 2007

Related Keywords:

  • Pancreatic Cancer
  • pancreatic cancer
  • Pancreatic Neoplasms

Name

Location

Vanderbilt-Ingram Cancer CenterNashville, Tennessee  37232-6838
Vanderbilt-Ingram Cancer Center - Cool SpringsNashville, Tennessee  37064
Vanderbilt-Ingram Cancer Center at FranklinNashville, Tennessee  37064