Developing Predictive Markers of Therapeutic Response in Pancreatic Cancer
N/A
N/A
Both
Pancreatic Cancer
Trial Information
Developing Predictive Markers of Therapeutic Response in Pancreatic Cancer
OBJECTIVES:
- To determine if a method of extracting and identifying biomarkers (i.e., secreted
cytokines and growth factors) from tissues of the quantity obtained from typical biopsy
can now be applied in the setting of pancreatic cancer
- To correlate pre-treatment biomarkers with recurrence, overall survival, and tumor
response to radiotherapy and chemotherapy in patients with pancreatic cancer.
OUTLINE: Tumor tissue specimens are obtained from the Vanderbilt Ingram Cancer Center Human
Tissue Acquisition Core and analyzed for biomarkers (e.g., integrity of DNA repair pathways
as analyzed by Rad51 and phosphorylated DNA-PK foci formation). The biomarkers are
correlated with clinical outcomes (recurrence, overall survival, and tumor response to
treatment).
Patients are followed for recurrence, relapse, and death from disease.
Inclusion Criteria
Inclusion criteria
- Diagnosis of pancreatic cancer
- Excess tissue collected at the time of routine surgery for pancreatic cancer must be
available for analysis
Exclusion criteria
- None known
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Determination if a method of extracting and identifying biomarkers from tissues of the quantity obtained from typical biopsy can be applied in the setting of pancreatic cancer
Outcome Time Frame:
1 year following final patient data
Safety Issue:
No
Principal Investigator
A. Bapsi Chakravarthy, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Food and Drug Administration
Study ID:
VICC GI 0666
NCT ID:
NCT00897832
Start Date:
January 2007
Completion Date:
December 2007
Related Keywords:
- Pancreatic Cancer
- pancreatic cancer
- Pancreatic Neoplasms
Name | Location |
|---|---|
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville, Tennessee 37064 |
| Vanderbilt-Ingram Cancer Center at Franklin | Nashville, Tennessee 37064 |
