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Developing In-Vivo Models of Human Breast Cancer


N/A
18 Years
N/A
Open (Enrolling)
Female
Breast Cancer

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Trial Information

Developing In-Vivo Models of Human Breast Cancer


OBJECTIVES:

- To develop new in vivo models of human breast cancer.

- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.

OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.

Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
to treatment.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of breast cancer

- Any stage of disease

- Primary or metastatic disease

- Human breast tumor tissues available after the diagnoses have been made

- Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103

- Have consented to the use of their tissues for research purpose

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Development of new in vivo models of human breast cancer

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

A. Bapsi Chakravarthy, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Vanderbilt University Human Research Protection Program

Study ID:

VICC BRE 0704

NCT ID:

NCT00897468

Start Date:

February 2007

Completion Date:

March 2014

Related Keywords:

  • Breast Cancer
  • breast cancer
  • Breast Neoplasms

Name

Location

Vanderbilt-Ingram Cancer CenterNashville, Tennessee  37232-6838
Vanderbilt-Ingram Cancer Center - Cool SpringsNashville, Tennessee  37064
Vanderbilt-Ingram Cancer Center at FranklinNashville, Tennessee  37064