Developing In-Vivo Models of Human Breast Cancer
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
Observational Model: Case-Only, Time Perspective: Prospective
Development of new in vivo models of human breast cancer
A. Bapsi Chakravarthy, MD
Vanderbilt-Ingram Cancer Center
United States: Vanderbilt University Human Research Protection Program
VICC BRE 0704
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|