Developing In-Vivo Models of Human Breast Cancer
18 Years
N/A
Female
Breast Cancer
Trial Information
Developing In-Vivo Models of Human Breast Cancer
OBJECTIVES:
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
to treatment.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of breast cancer
- Any stage of disease
- Primary or metastatic disease
- Human breast tumor tissues available after the diagnoses have been made
- Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103
- Have consented to the use of their tissues for research purpose
- Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Menopausal status not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Development of new in vivo models of human breast cancer
Outcome Time Frame:
1 year
Safety Issue:
No
Principal Investigator
A. Bapsi Chakravarthy, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Vanderbilt University Human Research Protection Program
Study ID:
VICC BRE 0704
NCT ID:
NCT00897468
Start Date:
February 2007
Completion Date:
March 2014
Related Keywords:
- Breast Cancer
- breast cancer
- Breast Neoplasms
Name | Location |
|---|---|
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee 37232-6838 |
| Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville, Tennessee 37064 |
| Vanderbilt-Ingram Cancer Center at Franklin | Nashville, Tennessee 37064 |
