Analysis of Intermediate Endpoint Biomarkers in the Respiratory Epithelium of Smokers Compared to Non-Smoking Controls
- Define the molecular and biochemical profiles of airway epithelium of smokers with no
disease, smokers with airflow obstruction and abnormal sputum cytology, and
- Assess the occurrence of abnormalities in non-smokers, smokers with no disease, smokers
with various grades of dysplasia, and smokers with lung cancer.
OUTLINE: Patients are stratified according to smoking status (smoker vs non-smoker) and
disease (no disease vs airflow obstruction and abnormal sputum cytology vs various grades of
dysplasia vs lung cancer).
Biological samples are collected and analyzed for future research studies.
PROJECTED ACCRUAL: A total of 78 patients will be accrued for this study.
Time Perspective: Prospective
Molecular and biochemical profiles
Upon completion of trial
York E. Miller, MD
University of Colorado, Denver
United States: Institutional Review Board
|University of Colorado Cancer Center at UC Health Sciences Center||Aurora, Colorado 80045|