Umbilical Cord Blood Transplantation as Treatment of Adult Patients With Hematologic Disorders
Patients must have a histologically confirmed diagnosis at The Vancouver General Hospital
or the BCCA-Vancouver.
Eligible patients will have one of the following underlying diseases:
- High risk acute lymphoblastic leukemia (ALL) in first complete remission, with high
risk being defined by the presence of t(4;11), t(9;22) or t(1;19) or patients
presenting with extreme hyperleukocytosis (WBC >100x109/L) or failure to achieve a
complete remission after standard induction therapy.
- Acute myeloid leukemia (AML) in first complete remission with high risk cytogenetics
or failure to achieve complete remission after standard induction therapy. ALL or AML
in second or subsequent remission
- Myelofibrosis with myeloid metaplasia.
- Chronic myeloid leukemia in chronic (failed interferon and/or Gleevec) or accelerated
- Myelodysplastic syndrome with IPSS risk category >Int-1
- Aplastic anemia
- Non-Hodgkin's lymphoma, chronic lymphocytic leukemia or Hodgkin's disease in relapse
or second or subsequent remission.
- Multiple Myeloma
- No active central nervous system (CNS) disease.
- No 9/10 or better HLA antigen matched related donor or VUD available.
- The patient's condition precludes waiting to search and find a VUD in the Unrelated
- Acceptance of standard blood product support
- Adequate organ function as defined by current Leukemia/BMT Program of BC standards
- Karnofsky performance status ≥ 80 (Appendix 10.2)
- Active infection
- Significant psychiatric disorder
- Progressive disease