Gene Expression Profiling of Metastatic Colon Cancer (CCCWFU 89B03)
N/A
N/A
Both
Colorectal Cancer, Metastatic Cancer
Trial Information
Gene Expression Profiling of Metastatic Colon Cancer (CCCWFU 89B03)
OBJECTIVES:
- Evaluate gene expression profiles in normal and tumor tissue from patients with colon
cancer metastatic to the liver, lungs, or peritoneum.
- Establish cell lines from primary colon tumors metastatic to the liver, lungs, or
peritoneum.
- Determine the specific gene expression changes that result in the manifestation of the
drug-resistant phenotype for each metastatic site.
OUTLINE: This is a pilot study.
Tumor and normal tissue collected during surgery are analyzed for gene expression profiling
by cDNA microarray. Tissue is also analyzed for thymidylate synthase (TS) gene expression by
quantitative PCR and for protein expression by western blot. Gene expression patterns are
correlated with TS levels.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of colon cancer metastatic to the liver, lungs, or peritoneum
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Retrospective
Outcome Measure:
Gene expression changes that occur at each metastatic site (i.e., liver, lungs, and peritoneum)
Outcome Time Frame:
day 1
Safety Issue:
No
Principal Investigator
Perry Shen, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Comprehensive Cancer Center of Wake Forest University
Authority:
United States: Institutional Review Board
Study ID:
CDR0000550060
NCT ID:
NCT00896753
Start Date:
September 2003
Completion Date:
May 2008
Related Keywords:
- Colorectal Cancer
- Metastatic Cancer
- stage IV colon cancer
- liver metastases
- lung metastases
- recurrent colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Neoplasm Metastasis
- Neoplasms
- Neoplasms, Second Primary
Name | Location |
|---|
