Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells
- Describe the complete hematopoietic transcriptomes of Fanconi cells of every common
complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic
cells derived from bone marrow of patients with Fanconi anemia.
- Define large-scale dynamic gene expression data in these patients.
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological
studies. Samples are analyzed for gene expression profiles using microarray assays.
PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this
Observational Model: Case Control, Time Perspective: Prospective
Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells
Grover C. Bagby, MD
OHSU Knight Cancer Institute
United States: Institutional Review Board
|Knight Cancer Institute at Oregon Health and Science University||Portland, Oregon 97239-3098|