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Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells


N/A
1 Year
55 Years
Not Enrolling
Both
Fanconi Anemia

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Trial Information

Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells


OBJECTIVES:

- Describe the complete hematopoietic transcriptomes of Fanconi cells of every common
complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic
cells derived from bone marrow of patients with Fanconi anemia.

- Define large-scale dynamic gene expression data in these patients.

OUTLINE: This is a multicenter study.

Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological
studies. Samples are analyzed for gene expression profiles using microarray assays.

PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this
study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Diagnosis of Fanconi anemia

- Requires bone marrow aspiration or biopsy for clinical purposes

- Healthy volunteer

- Over 18 years of age

- No known blood abnormality

PATIENT CHARACTERISTICS:

- Platelet count > 150,000/mm^3

- White Blood Cell(WBC) > 4,000/mm^3

- Hemoglobin > 13 g/dL

- No clinical signs or symptoms of acute or subacute infection (e.g., viral, bacterial,
or fungal)

- No allergies to lidocaine or xylocaine

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells

Safety Issue:

No

Principal Investigator

Grover C. Bagby, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

OHSU Knight Cancer Institute

Authority:

United States: Institutional Review Board

Study ID:

CDR0000445212

NCT ID:

NCT00896740

Start Date:

March 2002

Completion Date:

September 2007

Related Keywords:

  • Fanconi Anemia
  • Fanconi anemia
  • Anemia
  • Fanconi Anemia
  • Fanconi Syndrome

Name

Location

Knight Cancer Institute at Oregon Health and Science UniversityPortland, Oregon  97239-3098