The Effect of Beta-glucan on Faecal Microflora in Polypectomized Patients
Prebiotics, such as short- and long-chain fructo-oligosaccharides are fermented by the
microflora colonizing the gastrointestinal tract, and they selectively stimulate the growth
or the activity of one or limited number of bacteria within the intestine. Beta-glucans are
polysaccharides occurring in the bran of cereal grains, the cell wall of Saccharomyces
cerevisiae and bacteria, certain types of fungi, seaweed and many kinds of mushrooms. The
aim of this study is to determine the effect of the potential prebiotic beta-glucan on the
intestinal microflora, the bacterial enzyme activity (beta-glucuronidase and
beta-glucosidase) in the faeces, the faecal pH, and the concentration of faecal short-chain
fatty acid in polypectomized patients.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
To measure the effect of beta-glucan on fecal microflora (number of bacteria, bacterial enzyme activity, SCFA, pH).
Adamantini Kyriacou, Ass. Professor
Greece: Ethics Committee