Translation Study for Children and Adolescents With Low Grade Glioma
- To develop a better understanding of why low-grade glioma tumors develop in children
- To study genetic profiles that may predict response to treatment and provide clues to
how these tumors developed initially using tumor and blood samples from these patients.
OUTLINE: This is a multicenter study.
- Retrospective data collection (for participants recruited from study SIOP-LGG1): During
a follow-up appointment for study SIOP-LGG1, both biological parents* are asked to
complete a questionnaire about their family's cancer history. They may complete the
questionnaire either in the clinic or in their home. Participants may complete and
return the questionnaires at any time throughout the study.
- Prospective data collection (for participants recruited from study SIOP-LGG-2004): Both
biological parents* are asked to complete a family history questionnaire and provide
information about their family's cancer history. Participants may complete and return
the questionnaires at any time throughout the study.
NOTE: *In circumstances where either or both biological parents are unable to complete the
questionnaire, it may be completed by the patient diagnosed with low grade glioma (if they
are over 16 years old) or adoptive parents or guardians, if they feel they have the
knowledge to complete the questionnaire.
Tumor tissue and blood samples collected on SIOP-LGG1 or SIOP-LGG-2004 are analyzed for
genetic profiles predictive of response to treatment and for different patterns of tumor
development, natural tumor behavior, and tumor sensitivity to cancer therapies. Collected
family data are anonymised and linked to the biological sample collected. Samples are then
stored for future molecular genetic studies.
Identification of factors that could determine different patterns of tumor development, natural tumor behavior, and tumor sensitivity to therapies
David A. Walker
Queen's Medical Centre