Inclusion Criteria:

- Age superior or equal 18 years

- primitive ovarian adenocarcinoma histologically confirmed

- or peritoneal or fallopian tube adenocarcinoma histologically confirmed

- Progression or relapse within 12 months after the end of first line of platin based
chemotherapy

- association in first line with other anticancer agent is allowed (taxanes,
anthracyclines, alkylants or gemcitabine) and with an anti-angiogenic (bevacizumab,
sunitinib).

- intra-peritoneal chemotherapy in first line is possible

- No previous treatment with HER inhibitors (ex : gefitinib)

- HER status not necessary

- measurable lesions (RECIST criteria). and/or CA125 value higher than 2 fold the
normal value or CA125 higher than 2 fold nadir value (if no normalized) proved by two
samples distant of 1 month

- OMS inferior or equal 2.

- biological parameters as follow: creatininemia ≤ 150 µmol/L or clearance ≥ 50
mL/min,bilirubin ≤ 1,5 LNS,transaminases and or alcalin phosphatases ≤ 2 LNS without
hepatic metastasis or ≤ 3 LNS if hepatic metastasis,neutrophils ≥
1,5.109/L,plaquettes ≥ 100.109/L.

- normal FEV

- No previous treatment by chemotherapy, hormonotherapy, immunotherapy or radiotherapy
within 4 weeks before inclusion

- No concomitant treatment forbidden with lapatinib.

- No previous treatment by Amiodarone in 6 months before inclusion

- signed informed consent

Exclusion Criteria:

- Previous treatment with :

- intensive chemotherapy with autograft

- two lignes of chemotherapy

- previous total abdominal irradiation

- previous chemotherapy with anti-HER treatment

- History of brain or meningitis metastasis uncontrolled.

- Malignancies except for adequately treated carcinoma in situ of the cervix and/or
basal cell skin cancer.

- uncontrolled infectious pathology

- uncontrolled cardiovascular disease

- Patients with an active intestinal occlusion not permit oral treatment

- known hypersensibility to topotecan and its excipients

- Woman of childbearing potential who are unwilling or unable to use an acceptable
method to avoid pregnancy for the entire study period

- Individual deprived of liberty